The Effect of Rambutan Honey and Rutin on Decrease Blood Glucose and Increase Streptozotocin-Induced Rat Plasma Insulin

DOI

10.2991/978-94-6463-060-2_13How to use a DOI?

Keywords

Blood glucose; Diabetes; Insulin; Rambutan honey; Rutin

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to insulin work disorders, insulin secretion disorders, or both. Rambutan honey as a natural ingredient has been studied to reduce oxidative stress, protect pancreatic beta cells from damage, and can increase insulin secretion from pancreatic beta cells. Rutin as secondary antioxidants can increase insulin secretion, reduce free radical formation, and can stimulate pancreatic progenitor cells to form new cells. This study aims to determine the effect of rambutan honey on blood glucose and insulin levels in rats induced by streptozotocin compared to rutin. This research is a pure experimental study with a total sample of 24 experimental animals consisting of 4 groups, namely negative control (NC), positive control (PC), and 2 treatment groups (T1–T2). Glucose levels were measured using the GOD-PAP method and were analyzed statistically (T-dependent p < 0.05, Anova, Duncan p < 0.05). Insulin levels were measured using a mouse insulin ELISA-kit and were statistically analyzed (Anova, Duncan p < 0.05). The results showed that rambutan honey and rutin could significantly reduce blood glucose levels (p = 0.008 and p = 0.010). Data on insulin levels showed significant differences between groups (p = 0.000). The conclusion of this study is that rambutan honey and rutin can reduce blood glucose level and increase insulin levels because they are antioxidant agents which have antihyperglycemic effects.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Iis Inayati Rakhmat
AU  - Euis Reni Yuslianti
AU  - Welly Ratwita
AU  - Teja Koswara
AU  - Nurul Sofiana Mutiadewi
PY  - 2022
DA  - 2022/12/16
TI  - The Effect of Rambutan Honey and Rutin on Decrease Blood Glucose and Increase Streptozotocin-Induced Rat Plasma Insulin
BT  - Proceedings of The 13th Annual Scientific Conference of Medical Faculty, Universitas Jenderal Achmad Yani (ASCMF 2022)
PB  - Atlantis Press
SP  - 84
EP  - 94
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-060-2_13
DO  - 10.2991/978-94-6463-060-2_13
ID  - Rakhmat2022
ER  -