Hypocholesterolemic and Hypoglycemic Effects of Soursop Fruit (Annona muricata) Ethanolic Extract in High Fat Diet and Alloxan Induced Wistar Rats

DOI

10.2991/978-94-6463-060-2_17How to use a DOI?

Keywords

Annona muricata; Hypoglicemic; Hypocholesterolemic

Abstract

Annona muricata (soursop) is a plant belonging to the Annonaceae family. It’s a medicinal herb that’s been used for centuries as a natural cure for a number of diseases. Several investigations in animals showed that the bark and leaves of the plant possessed antihypertensive, vasodilator, anti-spasmodic, and cardio depressive. However, research on soursop fruit is still limited. This study aims to investigate the effect of soursop fruit ethanolic extract on blood glucose, total and Low-Density Lipoprotein (LDL) cholesterol levels in high fat diet and alloxan-induced rats (Rattus novergicus). The study was done experimentally with pre and posttest control group design using 30 rats divided into 6 groups consisted of normal group with standard diet, and five groups induced by high fat diet and alloxan then given 0.9 mg/kg of simvastatin, 0.5 mg/kg glibenclamide, 250 and 500 mg/kg of soursop fruit ethanolic extract (SFEE), and one diabetic hyperglycmia group as positive control without treatment. Blood glucose, total and LDL cholesterol levels measurement was conducted after 21 days of treatment. Data was analyzed using dependent t-test. Results shows significant reduction in blood glucose, total and LDL cholesterol level within treatment groups (p < 0.05). Furthermore, 500 mg/kg SFEE has roughly the same effectiveness as 0.9 mg/kg of simvastatin in reducing the total cholesterol level (p > 0.05), but not for LDL cholesterol. Meanwhile, the effectiveness of 250 and 500 mg/kg SFEE in lowering blood glucose levels is the same as glibenclamide (p > 0.05). In conclusion, SFEE shows hypoglycemic and hypocholesterolemic effect on both dosages.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Evi Sovia
AU  - Nurbaiti Nazarudin
AU  - Ilma Fiddiyanti
AU  - Dinyar Supriyadi
AU  - Wini Fatimah Junaidi
AU  - Hidayah Dwijayanti
AU  - Helmi Makarim
AU  - Aprilia Grace Sweetasari
PY  - 2022
DA  - 2022/12/16
TI  - Hypocholesterolemic and Hypoglycemic Effects of Soursop Fruit (Annona muricata) Ethanolic Extract in High Fat Diet and Alloxan Induced Wistar Rats
BT  - Proceedings of The 13th Annual Scientific Conference of Medical Faculty, Universitas Jenderal Achmad Yani (ASCMF 2022)
PB  - Atlantis Press
SP  - 119
EP  - 125
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-060-2_17
DO  - 10.2991/978-94-6463-060-2_17
ID  - Sovia2022
ER  -