Quantitative Efficacy Assessment of AAV2-EPO to DR

DOI

10.2991/aiie-15.2015.69How to use a DOI?

Keywords

diabetic retinopathy; MHSI; AAV2-EPO; ONL; qualitative analysis; spectral angle

Abstract

AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR)of experimental rats was studied by molecular hyper spectralimaging system (MHIS). Molecular hyper spectral images of rat retinal tissues lice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (lo w dose groupE1, middle dose groupE2, high dose groupE3). By quantitatively assessment of the thickness of the outer nuclear layer (ONL), the relative error of the spectrum, spectral similarity comparison on the spectrum angle and the correlation coefficient, it were proves thatAAV2-EPO has some efficacy to early diabetic retinopathy of rats.AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - H.Y. Liu
AU  - Q.L. Li
AU  - Y.F. Qian
AU  - J.F. Zhang
PY  - 2015/07
DA  - 2015/07
TI  - Quantitative Efficacy Assessment of AAV2-EPO to DR
BT  - Proceedings of the 2015 International Conference on Artificial Intelligence and Industrial Engineering
PB  - Atlantis Press
SP  - 246
EP  - 249
SN  - 1951-6851
UR  - https://doi.org/10.2991/aiie-15.2015.69
DO  - 10.2991/aiie-15.2015.69
ID  - Liu2015/07
ER  -