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Volume 2, Issue 1, February 2021, Pages 13 - 20

Neuroprotective Effect of Alkylresorcinols from Wheat Bran in HT22 Cells: Correlation with in vitro Antioxidant Activity

Authors
Yanyu Zou, Fengjiao Fan, Yong Fang*, Peng Li, Ji Xia, Xinchun Shen, Qin Liu, Qiuhui Hu
College of Food Science and Engineering, Nanjing University of Finance and Economics/Key Laboratory of Grains and Oils Quality Control and Processing/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China
*Corresponding author. Email: fangyong10@nufe.edu.cn
Corresponding Author
Yong Fang
Received 6 November 2020, Accepted 24 January 2021, Available Online 31 January 2021.
DOI
10.2991/efood.k.210125.001How to use a DOI?
Keywords
Wheat bran; alkylresorcinols; neuroprotective effect; antioxidation
Abstract

Alkylresorcinols (ARs), which are phenolic lipids found in wheat bran, have attracted a considerable amount of attention because of their antioxidant properties. However, the mechanism of ARs for regulating neuroprotective activity remains unclear. The correlation between the cellular neuroprotective effects of ARs in HT22 cells and their in vitro antioxidant activity were investigated. The results showed that two main constituents of crude ARs were C19:0 and C21:0, which was identified by high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. Pre-treatment with 400 μg/mL crude ARs could protect from H2O2-induced cellular damage involving low cell viability, leakage of lactate dehydrogenase and decreased superoxide dismutase activity. The maximum radical scavenging ability of DPPH•, ABTS•+, • O2− and •OH– was 85.45%, 88.89%, 84.42% and 87.36%. The neuroprotection effect of ARs was significantly correlated with in vitro antioxidant capacity, confirmed by the maximum correlation coefficients being 0.9988, –0.9974 and 0.9972. The antioxidation of ARs potentially promoted neuroprotective effect and further study is needed to clarify the other mechanism behind ARs benefits.

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Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
eFood
Volume-Issue
2 - 1
Pages
13 - 20
Publication Date
2021/01/31
ISSN (Online)
2666-3066
DOI
10.2991/efood.k.210125.001How to use a DOI?
Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Yanyu Zou
AU  - Fengjiao Fan
AU  - Yong Fang
AU  - Peng Li
AU  - Ji Xia
AU  - Xinchun Shen
AU  - Qin Liu
AU  - Qiuhui Hu
PY  - 2021
DA  - 2021/01/31
TI  - Neuroprotective Effect of Alkylresorcinols from Wheat Bran in HT22 Cells: Correlation with in vitro Antioxidant Activity
JO  - eFood
SP  - 13
EP  - 20
VL  - 2
IS  - 1
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.210125.001
DO  - 10.2991/efood.k.210125.001
ID  - Zou2021
ER  -