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Volume 1, Issue 1, February 2020, Pages 53 - 60

Can Natural Products Suppress Resistant Helicobacter pylori to Fight Against Gastric Diseases in Humans?

Authors
Li-Shu Wang1, Carla Elena Echeveste1, Jianhua Yu2, Yi-Wen Huang3, John Lechner1, Ling Mei4, Patrick Sanvanson4, Martha Yearsley5, Chin-Kun Wang6, Gary Stoner7, *
1Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
2Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA
3Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA
4Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
5Department of Pathology, Ohio State University, Columbus, OH, USA
6School of Nutrition, Chung Shan Medical University, Taichung City, Taiwan
7Department of Microbiology and Immunology, Montana State University, Bozeman, MT, USA
*Corresponding author. Email: gstoner@montana.edu
Corresponding Author
Gary Stoner
Received 15 October 2019, Accepted 29 January 2020, Available Online 19 February 2020.
DOI
10.2991/efood.k.200211.001How to use a DOI?
Keywords
Helicobacter pylori; natural products; resistant; gastric diseases; humans
Abstract

More than 50% of the world’s population is infected with Helicobacter pylori. H. pylori is the major causative agent of gastric ulcers and gastric cancer. H. pylori eradication using antibiotics either alone or together with a proton pump inhibitor is the primary strategy to decrease the incidence of gastric cancer. Although eradication therapy is effective, there are significant adverse effects and more importantly, resistance to antibiotics occurs, which represents a major therapeutic challenge. Multiple natural products have been shown to suppress H. pylori both in vitro and in animal model systems. However, only a handful of natural products have been evaluated in human clinical trials. The focus of this review is to summarize the results of published human clinical trials to assess the ability of natural products to reduce or eliminate H. pylori infections. Current evidence suggests that these products appear to have great potential to be developed as pharmaceutical candidates for eradication of H. pylori, hopefully both antibiotic-sensitive and antibiotic-resistant strains. Frequent consumption of locally produced foodstuff for controlling H. pylori infection in different countries around the world may well be a feasible long-term solution to fight against this worldwide prevalent pathogen.

Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
eFood
Volume-Issue
1 - 1
Pages
53 - 60
Publication Date
2020/02/19
ISSN (Online)
2666-3066
DOI
10.2991/efood.k.200211.001How to use a DOI?
Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Li-Shu Wang
AU  - Carla Elena Echeveste
AU  - Jianhua Yu
AU  - Yi-Wen Huang
AU  - John Lechner
AU  - Ling Mei
AU  - Patrick Sanvanson
AU  - Martha Yearsley
AU  - Chin-Kun Wang
AU  - Gary Stoner
PY  - 2020
DA  - 2020/02/19
TI  - Can Natural Products Suppress Resistant Helicobacter pylori to Fight Against Gastric Diseases in Humans?
JO  - eFood
SP  - 53
EP  - 60
VL  - 1
IS  - 1
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.200211.001
DO  - 10.2991/efood.k.200211.001
ID  - Wang2020
ER  -