A Meta-analysis on Vitamin D Deficiency in Patients with Sickle Cell Disease

Authors

Sagad Omer Obeid Mohamed^{1, *,} , Fatima Abdelhakam Abdellatif MohamedElmugadam², Hiba Faroug Mohamed Awadalla³, Abdalla Omer Obeid Mohamedali⁴, Mansour Osman Alhaj Alawad¹, Ahmed Abdulgadir Noureddin¹, Afnan Abugundul Ahmed Osman³, Esraa Mohamed Osman Mohamed¹, Gehad Abdelmonem Abdalla Ibrahim⁵, Malaz Ahmed Osman Elsayed³

¹Department of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, Sudan

²Institute of Endemic Diseases, Faculty of Medicine, University of Khartoum, Sudan

³Department of Internal Medicine, Faculty of Medicine, University of Khartoum, Sudan

⁴Department of Surgery, Faculty of Medicine, Shendi University, Sudan

⁵Education Development Center, Faculty of Medicine, University of Khartoum, Sudan

^*Corresponding author. Email: s.oom123@yahoo.com

DOI

10.2991/dsahmj.k.200717.001How to use a DOI?

Keywords

Vitamin D; sickle cell disease; meta-analysis

Abstract

Vitamin D Deficiency (VDD) is reported to be more frequent with serious clinical outcomes in patients with Sickle Cell Disease (SCD). There is a wide disparity in data in the existing literature regarding the prevalence and risk of VDD in patients with SCD. These data require further summary and analyses for better accuracy. This review aimed to assess the association between VDD and SCD, and was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Medline/PubMed, World Health Organization Virtual Health Library, ScienceDirect, and Google Scholar were used for the systematic search. A random effects model was used to estimate the pooled prevalence, Risk Ratio (RR), and Standardized Mean Difference (SMD) estimates with the corresponding 95% Confidence Interval (CI) using OpenMeta Analyst software version 10.10 (Tufts Medical Center, Boston, MA, USA). Twenty-five studies fulfilled the eligibility criteria. The prevalence of VDD among patients with SCD was 63.8% (95% CI, 52.5–75.1). The risk of VDD among patients with SCD was more than two times that of the general population (RR = 2.129; 95% CI, 1.024–4.423; p < 0.001). Serum vitamin D levels were significantly lower in SCD patients than in their controls (SMD = −1.883: 95% CI, −3.006 to −0.760; p < 0.001). This review provides a comprehensive view of the association between vitamin D status and SCD.

Copyright

© 2020 Dr. Sulaiman Al Habib Medical Group. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Sagad Omer Obeid Mohamed
AU  - Fatima Abdelhakam Abdellatif MohamedElmugadam
AU  - Hiba Faroug Mohamed Awadalla
AU  - Abdalla Omer Obeid Mohamedali
AU  - Mansour Osman Alhaj Alawad
AU  - Ahmed Abdulgadir Noureddin
AU  - Afnan Abugundul Ahmed Osman
AU  - Esraa Mohamed Osman Mohamed
AU  - Gehad Abdelmonem Abdalla Ibrahim
AU  - Malaz Ahmed Osman Elsayed
PY  - 2020
DA  - 2020/07/21
TI  - A Meta-analysis on Vitamin D Deficiency in Patients with Sickle Cell Disease
JO  - Dr. Sulaiman Al Habib Medical Journal
SP  - 95
EP  - 100
VL  - 2
IS  - 3
SN  - 2590-3349
UR  - https://doi.org/10.2991/dsahmj.k.200717.001
DO  - 10.2991/dsahmj.k.200717.001
ID  - Mohamed2020
ER  -