Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 167 - 168

4.4 ASSOCIATIONS BETWEEN OBJECTIVELY MEASURED PHYSICAL ACTIVITY ENERGY EXPENDITURE AND CENTRAL HAEMODYNAMICS. THE ADDITION-PRO STUDY

Authors
A.S.D. Laursen1, 2, A.-L.S. Hansen1, 3, N. Wiinberg4, S. Brage5, A. Sandbæk6, T. Lauritsen6, M.E. Jørgensen1, B. Kiens2, N.B. Johansen1, 7
1Steno Diabetes Center, Gentofte, Denmark
2Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
3Department of Clinical Immunology, Hospital of South West Jutland, Esbjerg, Denmark
4Department of Clinical Physiology, Frederiksberg Hospital, Copenhagen, Denmark
5MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom
6Department of Public Health, Section of General Practice, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
7Department of Clinical Pharmacology, Bispebjerg Hospital, Copenhagen, Denmark
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.022How to use a DOI?
Abstract

Objective. Physical activity (PA) has been associated with reduced cardiovascular disease (CVD). However, improvements in conventional risk factors do not explain the full benefit of PA on CVD risk. Therefore, we examined the association between PA and central haemodynamics to provide new insight into the link between PA and CVD.

Methods. We performed cross-sectional analyses of data from a health examination of 1,607 Danish adults at low to high diabetes risk. PA energy expenditure (PAEE) was measured by combined accelerometry and heart rate monitoring (ActiHeart®) expressed as kJ/kg/day. Aortic stiffness was assessed by applanation tonometry (SphygmoCor®), as aortic pulse wave velocity (aPWV), and central blood pressure was estimated from wave forms recorded at the radial artery. Associations between PAEE and central haemodynamics were examined by linear regression successively adjusted for sex, age, waist circumference, and smoking. Additionally, aPWV was adjusted for mean blood pressure. aPWV was logarithmically transformed. Individuals with previously myocardial or cerebral infarction were excluded (n = 183).

Results. Median age was 66 years (IQR: 61;71), 52% was men, median PAEE was 28 kJ/kg/day (IQR: 20;39), and median aPWV 8.0 m/s (IQR: 6.9;9.4). A higher PAEE of 10 kJ/kg/day was associated with a 1.0 % lower aPWV (CI: −0.17; −0.03). Associations with systolic blood pressure and pulse pressure were not statistically significant (−0.5 mmHg (CI: −0.11;0.01) and −0.02 mmHg (CI: −0.06;0.03)).

Conclusion. A higher level of PAEE is associated with lower levels of aortic stiffness indicating that the beneficial effects of PA on CVD are partially mediated by aortic stiffness.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
167 - 168
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.022How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - A.S.D. Laursen
AU  - A.-L.S. Hansen
AU  - N. Wiinberg
AU  - S. Brage
AU  - A. Sandbæk
AU  - T. Lauritsen
AU  - M.E. Jørgensen
AU  - B. Kiens
AU  - N.B. Johansen
PY  - 2013
DA  - 2013/11/11
TI  - 4.4 ASSOCIATIONS BETWEEN OBJECTIVELY MEASURED PHYSICAL ACTIVITY ENERGY EXPENDITURE AND CENTRAL HAEMODYNAMICS. THE ADDITION-PRO STUDY
JO  - Artery Research
SP  - 167
EP  - 168
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.022
DO  - 10.1016/j.artres.2013.10.022
ID  - Laursen2013
ER  -