P5.24 EFFECTS OF IVABRADINE AND ATENOLOL ON CENTRAL AORTIC PRESSURE IN HYPERTENSIVE PATIENTS WITH STABLE ANGINA

DOI

10.1016/j.artres.2013.10.172How to use a DOI?

Abstract

The aim of the study was to assess the effects of ivabradine (I) and atenolol (A) on central aortic pressure in patients with stable angina and arterial hypertension (AH).

Methods: The study was conducted on 31 hypertensive patients (57.1% male), mean age 61.9 ± 8.4 years, with angina pectoris of II-III functional class and without history of myocardial infarction and chronic heart failure. Two weeks before randomization all patients received nifedipine SR (30 mg o.d.) additionally to antihypertensive treatment. Then patients were randomly assigned to I (n=15) and A (n=16) dose up-titration for 2 weeks. Next 4 weeks doses of I and A were consistent. Mean doses were 14,4 mg for I and 137,5 mg for A. Heart rate, peripheral systolic (SBP) and diastolic blood pressure (DBP), central aortic systolic (CSP) and diastolic pressure (CDP), aortic pulse pressure (PP) were measured at baseline and at the end of the study.

Results: Heart rate (HR) decreased from 74.0 to 54.0 bpm with I and from 74.5 to 54.5 bpm with A (both p=0.001). SBP decreased from 132.0 to 129.5 mm Hg with I (p=0.55) and from 132.0 to 122.0 with A (p=0.01). DBP decreased from 80.0 to 79.5 mm Hg with I (p=0.96) and from 80.0 to 76.0 mm Hg mm Hg with A (p=0.001). CSP decreased by 6.9 mm Hg with I (p=0.01) and 8.0 mm Hg with A (p=0.002). DSP decreased by 3.0 mm Hg with I (p=0.01) and 4.0 mm Hg with A (p=0.004). PP decreased by 4.0 mm Hg after I (p=0.64), while PP increased by 5.0 mm Hg after A (p=0.76).

Conclusion: After achieving of target HR ivabradine without influence on peripheral BP decreased CSP compared with atenolol.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - A. Shavarov
AU  - G. Kiyakbaev
AU  - V. Moiseeyev
AU  - Z. Kobalava
PY  - 2013
DA  - 2013/11/11
TI  - P5.24 EFFECTS OF IVABRADINE AND ATENOLOL ON CENTRAL AORTIC PRESSURE IN HYPERTENSIVE PATIENTS WITH STABLE ANGINA
JO  - Artery Research
SP  - 150
EP  - 150
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.172
DO  - 10.1016/j.artres.2013.10.172
ID  - Shavarov2013
ER  -