P5.26 24 HOURS PULSATILE HEMODYNAMICS IN BORDERLINE VERSUS RESISTANT HYPERTENSIVES

T. Weber; B. Hametner; B. Eber; S. Wassertheurer

doi:10.1016/j.artres.2013.10.174

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Volume 7, Issue 3-4, September 2013, Pages 150 - 151

P5.26 24 HOURS PULSATILE HEMODYNAMICS IN BORDERLINE VERSUS RESISTANT HYPERTENSIVES

Authors

T. Weber¹, B. Hametner², B. Eber¹, S. Wassertheurer²

¹Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria

²Health & Environment Department, AIT Austrian Institute of Technology, Vienna, Austria

Available Online 11 November 2013.

DOI

10.1016/j.artres.2013.10.174 How to use a DOI?

Abstract

Background: Diurnal variations of brachial blood pressure have important prognostic implications. The aim of this study was to investigate differences in day- and night-time values of brachial and central hemodynamic parameters in two groups of borderline and resistant hypertensives.

Methods: We performed 24 hour pulse wave analysis, using a brachial cuff and validated ARCSolver algorithms. Central pressures were derived with a generalized transfer function using measured mean and diastolic pressure for calibration. 50 borderline hypertensives (BH; mean age: 52 years, mean 24h brachial blood pressure (bBP): 123/81 mmHg) and 25 resistant hypertensives (RH; mean age: 58 years, mean 24h bBP: 138/85 mmHg) were included in the study. Day-time was specified as 09:00–21:00 and night-time as 01:00–06:00.

Results: With respect to bSBP, we observed a dipping phenomenon (decrease > 10%) in BH, but not in RH. In contrast, with respect to cSBP, no dipping was present in both groups, respectively. Heart rate was significantly lower at night-time in both groups. Daytime and night-time bPP did not differ in both groups, but cPP showed an increase at night-time in both groups. All measures of wave reflection increased at night-time in both groups.

Conclusions: Measuring 24h pulsatile central hemodynamic parameters using a cuff device is feasible and can lead to novel insights compared to brachial BP. Further studies should investigate the clinical value.

		BH	RH
Brachial systolic BP (mmHg)	Day	127^*	139^$
Brachial systolic BP (mmHg)	Night	113	135^$
Central systolic BP (mmHg)	Day	128	144^$
Central systolic BP (mmHg)	Night	123	147^$
Brachial pulse pressure (mmHg)	Day	41	51^$
Brachial pulse pressure (mmHg)	Night	40	54^$
Central pulse pressure (mmHg)	Day	41^*	54^$
Central pulse pressure (mmHg)	Night	49	64^$
Heart rate (bpm)	Day	72^*	69^*
Heart rate (bpm)	Night	59	60
AIx	Day	23^*	29^*^$
AIx	Night	29	38^$
AIx@75	Day	22	25^*
AIx@75	Night	20	30^$
Amplitude backward wave (mmHg)	Day	16^*	22^*^$
Amplitude backward wave (mmHg)	Night	21	28^$
Reflection magnitude	Day	61^*	64^*
Reflection magnitude	Night	70	71

*

p<0.05 day vs night;

$

p<0.05 BH vs RH.

Open Access

This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 150 - 151
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.174 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - T. Weber
AU  - B. Hametner
AU  - B. Eber
AU  - S. Wassertheurer
PY  - 2013
DA  - 2013/11/11
TI  - P5.26 24 HOURS PULSATILE HEMODYNAMICS IN BORDERLINE VERSUS RESISTANT HYPERTENSIVES
JO  - Artery Research
SP  - 150
EP  - 151
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.174
DO  - 10.1016/j.artres.2013.10.174
ID  - Weber2013
ER  -

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