P5.07 DIFFERENT EFFECTS OF AGEING AND BP ON SEVERAL AORTIC AND CAROTID SEGMENTS

DOI

10.1016/j.artres.2013.10.156How to use a DOI?

Abstract

Objective: Carotid-femoral PWV (cfPWV) is a regional marker of vascular ageing: our aim was to take advantage of Magnetic Resonance (MRI) and High resolution Echotracking (HRE) in order to non-invasively investigate the effect of age and blood pressure (BP) on different segments of large arteries.

Methods: Regional stiffness was measured as cfPWV using Sphygmocor and as aortic arch PWV using MRI (ArchPWV). Local stiffness was measured at the carotid artery site using HRE (carPWV), and at the ascending and descending thoracic aorta sites using MRI (As and DsAoPWV). Local PWVs were calculated using Bramwell-Hill equation and all velocities were expressed in m/s. We included 72 normotensive non diabetic subjects (56.7% men), free from overt cardiovascular disease.

Results: In these 42±15 yrs-old subjects, having SBP/DBP 119±11/66±8 mmHg, PWV increased from proximal to distal segments: AsAoPWV=5.37±2.07 m/s; ArchPWV= 5.47±2.07 m/s; DsAoPWV=5.45±1.40 m/s; carPWV=5.79±1.5 m/s; and cfPWV=7.65±1.58 m/s. In univariate analysis, all PWVs strongly increased with age (r² ranging from 0.36 for ArchPWV to 0.54 for AsAoPWV; p<0.0001). The stiffness gradient between AsAoPWV and CarPWV reversed with ageing. (r=0.42, p<0.001). Mean blood pressure (MBP) was more strongly associated with CarPWV and cfPWV (r=0.53/0.71 respectively; p<0.001).

Conclusion: In this cohort of normotensive subjects we showed that age and BP had different effects on various segments of large proximal arteries. Age was a determinant of arterial stiffness in all carotid and aortic segments, with a more pronounced influence on AsAoPWV whereas MBP affected more aortic stiffness on the carotid-femoral pathway.

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TY  - JOUR
AU  - F. Tosello
AU  - M. Bensalah
AU  - H. Ketthab
AU  - N. Kachenoura
AU  - P. Boutouyrie
AU  - S. Laurent
AU  - E. Mousseaux
PY  - 2013
DA  - 2013/11/11
TI  - P5.07 DIFFERENT EFFECTS OF AGEING AND BP ON SEVERAL AORTIC AND CAROTID SEGMENTS
JO  - Artery Research
SP  - 145
EP  - 146
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.156
DO  - 10.1016/j.artres.2013.10.156
ID  - Tosello2013
ER  -