P5.07 DIFFERENT EFFECTS OF AGEING AND BP ON SEVERAL AORTIC AND CAROTID SEGMENTS

F. Tosello; M. Bensalah; H. Ketthab; N. Kachenoura; P. Boutouyrie; S. Laurent; E. Mousseaux

doi:10.1016/j.artres.2013.10.156

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Volume 7, Issue 3-4, September 2013, Pages 145 - 146

P5.07 DIFFERENT EFFECTS OF AGEING AND BP ON SEVERAL AORTIC AND CAROTID SEGMENTS

Authors

F. Tosello¹^{, 2}, M. Bensalah³, H. Ketthab¹, N. Kachenoura³, P. Boutouyrie¹, S. Laurent¹, E. Mousseaux³

¹Descartes University, Pharmacology Dpt, Paris, France

²Turin University, Medical Sciences Dpt, Turin, Italy

³Descartes University, Radioogy Dpt, Paris, France

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.156 How to use a DOI?
Abstract: Objective: Carotid-femoral PWV (cfPWV) is a regional marker of vascular ageing: our aim was to take advantage of Magnetic Resonance (MRI) and High resolution Echotracking (HRE) in order to non-invasively investigate the effect of age and blood pressure (BP) on different segments of large arteries.

Methods: Regional stiffness was measured as cfPWV using Sphygmocor and as aortic arch PWV using MRI (ArchPWV). Local stiffness was measured at the carotid artery site using HRE (carPWV), and at the ascending and descending thoracic aorta sites using MRI (As and DsAoPWV). Local PWVs were calculated using Bramwell-Hill equation and all velocities were expressed in m/s. We included 72 normotensive non diabetic subjects (56.7% men), free from overt cardiovascular disease.

Results: In these 42±15 yrs-old subjects, having SBP/DBP 119±11/66±8 mmHg, PWV increased from proximal to distal segments: AsAoPWV=5.37±2.07 m/s; ArchPWV= 5.47±2.07 m/s; DsAoPWV=5.45±1.40 m/s; carPWV=5.79±1.5 m/s; and cfPWV=7.65±1.58 m/s. In univariate analysis, all PWVs strongly increased with age (r² ranging from 0.36 for ArchPWV to 0.54 for AsAoPWV; p<0.0001). The stiffness gradient between AsAoPWV and CarPWV reversed with ageing. (r=0.42, p<0.001). Mean blood pressure (MBP) was more strongly associated with CarPWV and cfPWV (r=0.53/0.71 respectively; p<0.001).

Conclusion: In this cohort of normotensive subjects we showed that age and BP had different effects on various segments of large proximal arteries. Age was a determinant of arterial stiffness in all carotid and aortic segments, with a more pronounced influence on AsAoPWV whereas MBP affected more aortic stiffness on the carotid-femoral pathway.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 145 - 146
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.156 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - F. Tosello
AU  - M. Bensalah
AU  - H. Ketthab
AU  - N. Kachenoura
AU  - P. Boutouyrie
AU  - S. Laurent
AU  - E. Mousseaux
PY  - 2013
DA  - 2013/11/11
TI  - P5.07 DIFFERENT EFFECTS OF AGEING AND BP ON SEVERAL AORTIC AND CAROTID SEGMENTS
JO  - Artery Research
SP  - 145
EP  - 146
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.156
DO  - 10.1016/j.artres.2013.10.156
ID  - Tosello2013
ER  -

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