Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 140 - 140

P4.17 ACUTE DIETARY SODIUM CHANGES IS A PHYSIOLOGICAL DETERMINANT OF AORTIC STIFFNESS

Authors
H. Ribeiro1, M. Briet1, A. Blanchard1, E. Curis1, X. Jeunemaitre1, 2, M. Azizi1
1Centre d’investigation clinique 9201, Hôpital européen Georges-Pompidou, AP-HP, Université Paris-Descartes, Inserm, Paris, France
2Service de Génétique, Hôpital européen Georges-Pompidou, AP-HP, Université Paris-Descartes, Inserm, Paris, France
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.135How to use a DOI?
Abstract

Objective: Aortic stiffness evaluation is recommended in standard care as hypertension target organ damage. The main determinants of aortic stiffness are age and blood pressure. We aimed to evaluate the impact of short-term extracellular volume changes induced by dietetic and pharmacological interventions on aortic stiffness.

Methods: 74 healthy male subjects, age (median [IQR]) 23,9 [5,7] years, non-smokers, were assigned to a low sodium/high potassium diet during seven days, followed by a high sodium/low potassium diet for 14 days, the last seven with concomitant administration of amiloride. Carotid-femoral pulse wave velocity (PWV) (SphygmoCor®) was measured at baseline, 7th, 15th and 21st days.

Results: PWV was stable during the low sodium/high potassium diet, significantly decreased during the high sodium/low potassium diet (−0,4 m/s, CI 95% −0,7 to −0.2, p<0.001) (day 7 to 15), and came back to baseline after the concomitant administration of amiloride (day 15 to day 21). In a mixed model analysis, mean daytime blood pressure (MBP), age and visit day 15 were independent determinants of changes in PWV. For each increase of 10 mmHg on MBP, PWV increased by 0,3 m/s (CI 95% 0,1 to 0,5, p=0,006), for each increase of 10 years of age, PWV increased by 0,4 m/s (CI 95% 0,1 to 0,7, p=0,01), and at visit 15 (high salt diet), PWV decreased by 0.3 m/s (CI 95 %, −0,52 to −0,12, p=0,002).

Conclusions: Short-time increase in extracellular volume is associated with a signification decrease in aortic stiffness in a blood pressure independent manner.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
140 - 140
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.135How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - H. Ribeiro
AU  - M. Briet
AU  - A. Blanchard
AU  - E. Curis
AU  - X. Jeunemaitre
AU  - M. Azizi
PY  - 2013
DA  - 2013/11/11
TI  - P4.17 ACUTE DIETARY SODIUM CHANGES IS A PHYSIOLOGICAL DETERMINANT OF AORTIC STIFFNESS
JO  - Artery Research
SP  - 140
EP  - 140
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.135
DO  - 10.1016/j.artres.2013.10.135
ID  - Ribeiro2013
ER  -