Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 140 - 140

P4.16 EFFECT OF DENERVATION ON VISCOELASTIC PROPERTIES OF LARGE ARTERIES IN POLYCYSTIC KIDNEY DISEASE RATS

Authors
Z. Kouchaki, G. Lindesay, M. Butlin, J.K. Phillips, A.P. Avolio
Australian School of Advanced Medicine, Macquarie University, Sydney, Australia
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.134How to use a DOI?
Abstract

Objectives: Arterial elasticity is determined by passive mechanical properties of wall components modulated by neurogenic effects on smooth muscle. We assessed denervation effects on viscoelastic properties of the aorta of Lewis Polycystic Kidney (LPK) disease rats, compared to controls (Lewis).

Methods: Abdominal aortic pressure (intravascular, Scisence) and diameter (ultrasound, Artlab) was measured in anesthetised (urethane, 1.3 g/kg) Lewis (n=11) and LPK (n=5) rats before and following denervation by ganglionic blockade (intravenous hexamethonium, 20 mg/kg). Bolus intravenous doses of vasoactive agents (6 μg phenylephrine or sodium nitroprusside) were used to study the rats at mean pressures of 75, 100, 125 and 150 mmHg. Complex elastic modulus (Ec) was calculated from the Fourier decomposition of pressure and diameter. Viscoelasticity (VE=Im(Ec)) was compared between LPK and Lewis rats in the intact and denervated state across the first three harmonics. Pressure dependency of viscoelasticity was studied using a frequency (thus heart rate) normalised viscoelastic term (VEN=VE/frequency).

Results: VE increased with frequency in all but Lewis rats at 150 mmHg. LPK rats had higher VE than Lewis (p<0.05), other than denervated rats at 150 mmHg and intact rats at 75 mmHg. Denervation reduced VE in both LPK and Lewis groups (p<0.05). VEN increased with pressure (p<0.001, Figure).

Conclusions: Aortic viscoelasticty was generally greater in LPK rats and was reduced with denervation. This study shows possible relationships between aortic compliance in polycystic kidney disease and sympathetic dysregulation.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
140 - 140
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.134How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Z. Kouchaki
AU  - G. Lindesay
AU  - M. Butlin
AU  - J.K. Phillips
AU  - A.P. Avolio
PY  - 2013
DA  - 2013/11/11
TI  - P4.16 EFFECT OF DENERVATION ON VISCOELASTIC PROPERTIES OF LARGE ARTERIES IN POLYCYSTIC KIDNEY DISEASE RATS
JO  - Artery Research
SP  - 140
EP  - 140
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.134
DO  - 10.1016/j.artres.2013.10.134
ID  - Kouchaki2013
ER  -