P3.03 INTERNATIONAL COMPARISON OF ESTIMATED AORTIC PULSE WAVE VELOCITY (APWV) IN 3 SETTINGS OF AFRICAN- AND EUROPEAN- ORIGIN PATIENTS AND CONTROLS – GHANA, BRITAIN AND BARBADOS

DOI

10.1016/j.artres.2013.10.091How to use a DOI?

Abstract

Objectives: In resource-poor settings, aPWV’s prognostic power, independent of blood pressure (BP), has potential as an intervention target against ‘hypertension’ and diabetes (T2DM). We compared simple determinants of aPWV in 3 African-origin settings and British Europeans.

Methods: Using methods standardised across 3 hospital sites in Ghana, Britain and Barbados, aPWV was estimated over 8 cardiac cycles up to 3 times by the single cuff-based Arteriograph, whose prognostic impact was recently reported. Sub-samples had repeatability measured separately. With basic anthropometry, data were analysed by regression (MRA), adjusting for temperature (co-linear with site).

Results: 527 people, (Ghana 296; UK 128 (35% African-origin); Barbados 103) 54% women, had satisfactory measurements, in 125 hypertensives without T2DM, 248 T2DMs and 154 apparently healthy controls, mean±SD age 50±15, range 20–87y, BMI 28.1±6 kg/m². Cross-site age-/sex / adjusted mean (SD) aPWV were 8.8±1.6, 9.3±2.3 and 8±1.8 m/sec for Ghana, UK & Barbados respectively, with sys/diasBP 147±23/ 85±13, 136±17/82±13 and 126±26/72±15 mmHg. Forced into the MRA model, patient group, BMI and temperature did not contribute while systolic BP (standardized Beta (=B) 0.28), age (0.26) site (0.22) or ethnicity as West African, African-Caribbean > European (0.3), heart rate (0.21) and gender (0.17), were all related to aPWV, p<0.002. Pulse, rather than systolic, pressure did not contribute, but central sysBP did (0.3, p<0.0001).

Conclusions: These data suggest that aPWV is not only a robust prognostic indicator but a potential treatment target, across the range of BP less affected by anthropometry and these ‘disease’ states. Are ethnic effects confounded by BP?

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - K. Connell
AU  - K. Yeboah
AU  - V. Govoni
AU  - C. Robinson
AU  - M.L. Casagrande
AU  - A. Amoah
AU  - J.K. Cruickshank
PY  - 2013
DA  - 2013/11/11
TI  - P3.03 INTERNATIONAL COMPARISON OF ESTIMATED AORTIC PULSE WAVE VELOCITY (APWV) IN 3 SETTINGS OF AFRICAN- AND EUROPEAN- ORIGIN PATIENTS AND CONTROLS – GHANA, BRITAIN AND BARBADOS
JO  - Artery Research
SP  - 127
EP  - 127
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.091
DO  - 10.1016/j.artres.2013.10.091
ID  - Connell2013
ER  -