P3.02 MORNING BLOOD PRESSURE SURGE, BLOOD PRESSURE VARIABILITY AND AORTIC STIFFNESS IN ESSENTIAL HYPERTENSION

G. Pucci; F. Battista; G. Bilo; G. Parati; G. Schillaci

doi:10.1016/j.artres.2013.10.090

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Volume 7, Issue 3-4, September 2013, Pages 127 - 127

P3.02 MORNING BLOOD PRESSURE SURGE, BLOOD PRESSURE VARIABILITY AND AORTIC STIFFNESS IN ESSENTIAL HYPERTENSION

Authors

G. Pucci¹, F. Battista¹, G. Bilo², G. Parati²^{, 3}, G. Schillaci¹

¹Department of Medicine, University of Perugia, Unit of Internal Medicine, Terni, Italy

²Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano, Milano, Italy

³Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milano, Italy

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.090 How to use a DOI?
Abstract: Morning blood pressure surge is associated with increased cardiovascular risk, possibly due to its ability to reflect short-term BP variability and/or its link with arterial stiffness. The link between morning BP surge and vascular stiffness is not defined.

689 untreated hypertensives (48±10 years, BP 149/92±17/10 mmHg) underwent c-f PWV and 24-h ambulatory BP measurement. Morning surge was calculated as: sleep-trough surge (STS, 2-hour average SBP after wake-up minus average of 3 SBP centered on the lowest nighttime reading), pre-awakening surge (PAS, 2-hour average SBP after wake-up minus 2-hour average SBP before wake-up), and rising BP surge (RBS, SBP on rising minus the lowest SBP in the 30’before). Average real variability (ARV, 24h average of the absolute differences between consecutive SBP), was considered a measure of short-term SBP variability.

STS and RBS were directly correlated to cfPWV (r=0.17 and r=0.12,p<0.01) and ARV (r=0.28 and r=0.23,p<0.001), while PAS had no such relationships. Patients in the top quartile of STS (>39 mmHg) had higher age- and 24-h mean BP-adjusted cfPWV (9.73±2 vs 9.29±2 m/s, p=0.004), while no difference was found for the top quartile of PAS or RBS. In a multivariate regression, high STS values predicted a high cfPWV (β=0.08,p=0.038), independently of age, sex, 24-h mean BP and nocturnal BP reduction. After adding ARV (β=0.17,p<0.001) to the model, the relationship between STS and cfPWV was no longer significant (β=0.05,p=0.17).

Morning SBP surge, calculated as STS, has a positive relation with aortic stiffness in hypertension, which is no longer significant after adjusting for 24-h short-term BP variability.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 127 - 127
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.090 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - G. Pucci
AU  - F. Battista
AU  - G. Bilo
AU  - G. Parati
AU  - G. Schillaci
PY  - 2013
DA  - 2013/11/11
TI  - P3.02 MORNING BLOOD PRESSURE SURGE, BLOOD PRESSURE VARIABILITY AND AORTIC STIFFNESS IN ESSENTIAL HYPERTENSION
JO  - Artery Research
SP  - 127
EP  - 127
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.090
DO  - 10.1016/j.artres.2013.10.090
ID  - Pucci2013
ER  -

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