Relationship between Obesity Phenotypes and Cardiovascular Risk in a Chinese Cohort
These two authors contributed equally to this work.
- DOI
- 10.2991/artres.k.200306.001How to use a DOI?
- Keywords
- Body mass index; obesity; metabolic syndrome; cardiovascular risk
- Abstract
Objective: The changing living patterns in China are accompanied by an increase in prevalence of cardiovascular disease for which obesity is a significant factor. This study investigated the association between obesity phenotypes and risk of cardiovascular disease in a Chinese cohort.
Methods: A sample of 10,826 community-dwelling individuals aged 40–79 years (mean age 62.2 ± 12.0 years) were stratified by categories of body mass index (BMI) (normal weight: BMI < 24 kg/m2; overweight: BMI of 25–28 kg/m2; obese: BMI > 28 kg/m2) and metabolic status and divided into six phenotypes: (1) normal metabolic status and normal weight; (2) normal metabolic status and overweight; (3) normal metabolic status and obese; (4) normal weight and dysmetabolic status; (5) dysmetabolic status and overweight; (6) dysmetabolic status and obese. The Atherosclerotic Cardiovascular Disease (ASCVD) risk score was determined based on cardiovascular risk factors.
Results: Prevalence of overweight and obesity was 15.2% and 25.2% respectively. After adjusting for confounding factors, ASCVD score was significantly higher in men [Odds Ratio (OR): 9.796, 95% confidence interval (CI): 5.833–16.450; p < 0.001] and women [OR: 5.821, 95% CI: 4.253–7.968; p < 0.001] with obese and dysmetabolic status compared to normal. The odds of reporting ASCVD risk was significantly higher in men (OR: 3.432, 95% CI: 1.965–5.996; p < 0.001) and women (OR: 4.647, 95% CI: 3.327–6.491; p < 0.001) with obese and dysmetabolic status compared to those with obese and normal metabolic status. In addition, the odds of reporting ASCVD risk was significantly lower in men (OR: 0.317, 95% CI: 0.142–0.707; p = 0.005) and women (OR: 0.487, 95% CI: 0.320–0.739; p = 0.001) with the overweight–dysmetabolic status phenotype compared to those with an overweight–normal metabolic phenotype.
Conclusion: Obese dysmetabolic individuals had the highest ASCVD risk score in all phenotypes. When BMI category was overweight, BMI played a more important role than metabolic status, whereas when BMI category was obesity, risk was more affected by metabolic status.
- HIGHLIGHTS
What is already known about this subject?
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Obesity presents a major risk for cardiovascular disease.
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Some studies provide evidence that obesity has better outcome compared to lean counterparts.
What does this study add?
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This study provides information that obese dysmetabolic individuals show the highest Atherosclerotic Cardiovascular Disease (ASCVD) risk score in all phenotypes in the whole cohort.
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This study also indicates that body mass index (BMI) plays a more important role for estimation of CV risk than metabolic status in overweight, whereas risk is more affected by metabolic status in obesity.
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- Copyright
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
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TY - JOUR AU - Yueliang Hu AU - Shuping Zheng AU - Jiehui Zhao AU - Isabella Tan AU - Mark Butlin AU - Alberto Avolio AU - Junli Zuo PY - 2020 DA - 2020/03/13 TI - Relationship between Obesity Phenotypes and Cardiovascular Risk in a Chinese Cohort JO - Artery Research SP - 34 EP - 41 VL - 26 IS - 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.200306.001 DO - 10.2991/artres.k.200306.001 ID - Hu2020 ER -