Artery Research

Volume 26, Issue 1, March 2020, Pages 34 - 41

Relationship between Obesity Phenotypes and Cardiovascular Risk in a Chinese Cohort

Authors
Yueliang Hu1, , Shuping Zheng2, , Jiehui Zhao3, Isabella Tan4, Mark Butlin4, Alberto Avolio4, Junli Zuo1, 4, *
1Department of Geriatric Medicine, Shanghai Jiatong School of Medicine, Ruijin Hospital North, Shanghai, China
2Department of General practice, Jiading District Jiangqiao Community Health Service Center, Shanghai, China
3Department of General practice, Daning Community Health Service Center, Shanghai, China
4Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

These two authors contributed equally to this work.

*Corresponding author. Email: zuo-junli@163.com
Corresponding Author
Junli Zuo
Received 15 February 2020, Accepted 21 February 2020, Available Online 13 March 2020.
DOI
10.2991/artres.k.200306.001How to use a DOI?
Keywords
Body mass index; obesity; metabolic syndrome; cardiovascular risk
Abstract

Objective: The changing living patterns in China are accompanied by an increase in prevalence of cardiovascular disease for which obesity is a significant factor. This study investigated the association between obesity phenotypes and risk of cardiovascular disease in a Chinese cohort.

Methods: A sample of 10,826 community-dwelling individuals aged 40–79 years (mean age 62.2 ± 12.0 years) were stratified by categories of body mass index (BMI) (normal weight: BMI < 24 kg/m2; overweight: BMI of 25–28 kg/m2; obese: BMI > 28 kg/m2) and metabolic status and divided into six phenotypes: (1) normal metabolic status and normal weight; (2) normal metabolic status and overweight; (3) normal metabolic status and obese; (4) normal weight and dysmetabolic status; (5) dysmetabolic status and overweight; (6) dysmetabolic status and obese. The Atherosclerotic Cardiovascular Disease (ASCVD) risk score was determined based on cardiovascular risk factors.

Results: Prevalence of overweight and obesity was 15.2% and 25.2% respectively. After adjusting for confounding factors, ASCVD score was significantly higher in men [Odds Ratio (OR): 9.796, 95% confidence interval (CI): 5.833–16.450; p < 0.001] and women [OR: 5.821, 95% CI: 4.253–7.968; p < 0.001] with obese and dysmetabolic status compared to normal. The odds of reporting ASCVD risk was significantly higher in men (OR: 3.432, 95% CI: 1.965–5.996; p < 0.001) and women (OR: 4.647, 95% CI: 3.327–6.491; p < 0.001) with obese and dysmetabolic status compared to those with obese and normal metabolic status. In addition, the odds of reporting ASCVD risk was significantly lower in men (OR: 0.317, 95% CI: 0.142–0.707; p = 0.005) and women (OR: 0.487, 95% CI: 0.320–0.739; p = 0.001) with the overweight–dysmetabolic status phenotype compared to those with an overweight–normal metabolic phenotype.

Conclusion: Obese dysmetabolic individuals had the highest ASCVD risk score in all phenotypes. When BMI category was overweight, BMI played a more important role than metabolic status, whereas when BMI category was obesity, risk was more affected by metabolic status.

HIGHLIGHTS

What is already known about this subject?

  • Obesity presents a major risk for cardiovascular disease.

  • Some studies provide evidence that obesity has better outcome compared to lean counterparts.

What does this study add?

  • This study provides information that obese dysmetabolic individuals show the highest Atherosclerotic Cardiovascular Disease (ASCVD) risk score in all phenotypes in the whole cohort.

  • This study also indicates that body mass index (BMI) plays a more important role for estimation of CV risk than metabolic status in overweight, whereas risk is more affected by metabolic status in obesity.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - 1
Pages
34 - 41
Publication Date
2020/03/13
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.200306.001How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Yueliang Hu
AU  - Shuping Zheng
AU  - Jiehui Zhao
AU  - Isabella Tan
AU  - Mark Butlin
AU  - Alberto Avolio
AU  - Junli Zuo
PY  - 2020
DA  - 2020/03/13
TI  - Relationship between Obesity Phenotypes and Cardiovascular Risk in a Chinese Cohort
JO  - Artery Research
SP  - 34
EP  - 41
VL  - 26
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200306.001
DO  - 10.2991/artres.k.200306.001
ID  - Hu2020
ER  -