Artery Research

Volume 26, Issue 1, March 2020, Pages 42 - 47

Validation of a Method to Estimate Stroke Volume from Brachial-cuff Derived Pressure Waveforms

Authors
Thomas Weber1, *, Siegfried Wassertheurer2, Jessica Middlemiss3, Carmel Mary McEniery3, Bernhard Hametner2, Christopher Clemens Mayer2, Ronald Karl Binder1, Hans-Josef Feistritzer4, Gert Klug5, Bernhard Metzler5
1Department for Internal Medicine II (Cardiology, Intensive Care Medicine), Klinikum Wels-Grieskirchen, Wels, Austria
2Center for Health and Bioresources, Austrian Institute of Technology, Vienna, Austria
3Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK
4Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany
5University Clinic for Internal Medicine III (Cardiology and Angiology), University Clinic Innsbruck, Austria
*Corresponding author. Email: thomas.weber3@liwest.at
Corresponding Author
Thomas Weber
Received 8 December 2019, Accepted 17 February 2020, Available Online 2 March 2020.
DOI
10.2991/artres.k.200223.001How to use a DOI?
Keywords
Stroke volume; validation study; hemodynamic model
Abstract

Background: Steady state hemodynamics [Stroke Volume - SV, cardiac output, peripheral resistance (Rp)] have attracted researchers in hypertension for decades. However, due to technical difficulties, they never entered clinical medicine.

Objective: To investigate the performance of a model-based algorithm, utilizing brachial pressure waveforms obtained with a cuff, to estimate stroke volume. The model combines a modified three-element like Windkessel system and transmission line theory.

Participants and Methods: In study 1, 97 patients with reperfused acute myocardial infarction and two healthy controls underwent cardiac magnetic resonance imaging (1.5 Tesla Magnetom, Siemens, Germany), and SV was measured with standard protocols from short axis cine images (11 slices). In study 2, 19 healthy individuals (12 females) had SVs measured with inert gas rebreathing at rest, and during light exercise (20 watts) on a bicycle ergometer. In both studies, model-based SV, estimated with a brachial cuff, was the comparator.

Results: In study 1, both SVs were moderately correlated (r = 0.54, p < 0.001). Using the method of Bland–Altman, mean difference between both methods was 8.7 ml (1.96 limits of agreement were 36.7 and –19.3 ml), with no systematic bias. In study 2, both SVs were moderately correlated at rest (r = 0.63, p = 0.004) and at light exercise (r = 0.70, p = 0.0057). Using the method of Bland–Altman, mean difference between both methods was 8.6 ml (1.96 limits of agreement were 39.2 and –22.0 ml) at rest, and 42.7 ml (1.96 limits of agreement were 95.4 and –10.1 ml) at light exercise.

Conclusion: Brachial oscillometry and mathematical modeling provide a reasonable estimate of SV under static conditions, which may be a useful addition to 24-h measurements of blood pressure and pulsatile hemodynamics.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - 1
Pages
42 - 47
Publication Date
2020/03/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.200223.001How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Thomas Weber
AU  - Siegfried Wassertheurer
AU  - Jessica Middlemiss
AU  - Carmel Mary McEniery
AU  - Bernhard Hametner
AU  - Christopher Clemens Mayer
AU  - Ronald Karl Binder
AU  - Hans-Josef Feistritzer
AU  - Gert Klug
AU  - Bernhard Metzler
PY  - 2020
DA  - 2020/03/02
TI  - Validation of a Method to Estimate Stroke Volume from Brachial-cuff Derived Pressure Waveforms
JO  - Artery Research
SP  - 42
EP  - 47
VL  - 26
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200223.001
DO  - 10.2991/artres.k.200223.001
ID  - Weber2020
ER  -