P129 Arterial Stiffness in Bicuspid or Tricuspid Aortic Valve Aortopathy Using Magnetic Resonance Imaging: Crossing the Physical and Hemodynamic limits?

Ariel Pascaner; Sophia Houriez—Gombaud-Saintonge; Gilles Soulat; Umit Gencer; Thomas Dietenbeck; Yasmina Chenoune; Nadjia Kachenoura; Elie Mousseaux; Damian Craiem; Emilie Bollache

doi:10.2991/artres.k.191224.155

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Volume 25, Issue Supplement 1, December 2019, Pages S170 - S170

P129 Arterial Stiffness in Bicuspid or Tricuspid Aortic Valve Aortopathy Using Magnetic Resonance Imaging: Crossing the Physical and Hemodynamic limits?

Authors

Ariel Pascaner¹, Sophia Houriez—Gombaud-Saintonge²^{, 3}, Gilles Soulat⁴, Umit Gencer⁴, Thomas Dietenbeck², Yasmina Chenoune³, Nadjia Kachenoura², Elie Mousseaux⁴, Damian Craiem¹, Emilie Bollache²^{, *}

¹IMETTYB – CONICET – Universidad Favaloro, Buenos Aires

²Sorbonne Université, INSERM, CNRS, Laboratoire d’Imagerie Biomédicale, Paris

³ESME Sudria Research Lab, Paris

⁴Hôpital Européen Georges-Pompidou, Paris

^*Corresponding author. Email: emilie.bollache@inserm.fr

Corresponding Author

Emilie Bollache

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.155 How to use a DOI?
Abstract: Purpose: To provide a comprehensive assessment of aortic stiffness, through both local and regional distensibility and pulse wave velocity (PWV), in patients with either a tricuspid (TAV) or bicuspid (BAV) aortic valve and/or aortic dilation using MRI.

Methods: We included 18 patients with TAV and dilated ascending aorta (DTAV, 65 ± 14 years, 11 males), 19 patients with a non-stenotic BAV without severe regurgitation (55 ± 15 years, 17 males), both paired for age, gender and pressures to control groups. All subjects underwent thoracic aortic axial 2D+t and sagittal 3D+t velocity-encoded MRI and carotid applanation tonometry. Local ascending (AA) and descending (DA) aortic distensibility as well as aortic arch PWV were automatically measured from 2D+t data [1], while regional AA and DA PWV were calculated from 3D+t data [2].

Results: As expected, both DTAV and BAV groups showed significantly increased maximal aortic diameters when compared to their respective control group: 47 ± 5 vs 31 ± 3 mm and 44 ± 4 vs 31 ± 4 mm, respectively (p < 0.001). However, no significant changes were found in local and regional aortic stiffness indices between both patient groups and their matched controls (p ≥ 0.05).

Conclusion: 2D or 3D data-derived distensibility or PWV concomitantly and unexpectedly indicate that aortic stiffness was unchanged in patients with aortopathy when compared to matched healthy controls. Since fundamental laminal flow conditions and elastic properties driving Moens-Korteweg models are not reached in highly dilated aortas, the associated turbulent flow, local flow disorganization, changes in derived pressure gradients and flow-wall forces might be more suitable for an early discrimination of patients with valve/aneurismal disease.
Copyright: © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]A Herment, N Kachenoura, M Lefort, M Bensalah, A Dogui, F Frouin, et al., Automated segmentation of the aorta from phase contrast MR images: validation against expert tracing in healthy volunteers and in patients with a dilated aorta, J Magn Reson Imaging, Vol. 31, 2010, pp. 881-8.

[2]S Houriez—Gombaud-Saintonge, E Mousseaux, I Bargiotas, A De Cesare, T Dietenbeck, K Bouaou, et al., The assessment of aortic pulse wave velocity using 4D flow magnetic resonance imaging: methods comparison, CinC, Vol. 44, 2017, pp. 1-4.

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S170 - S170
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.155 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Ariel Pascaner
AU  - Sophia Houriez—Gombaud-Saintonge
AU  - Gilles Soulat
AU  - Umit Gencer
AU  - Thomas Dietenbeck
AU  - Yasmina Chenoune
AU  - Nadjia Kachenoura
AU  - Elie Mousseaux
AU  - Damian Craiem
AU  - Emilie Bollache
PY  - 2020
DA  - 2020/02/17
TI  - P129 Arterial Stiffness in Bicuspid or Tricuspid Aortic Valve Aortopathy Using Magnetic Resonance Imaging: Crossing the Physical and Hemodynamic limits?
JO  - Artery Research
SP  - S170
EP  - S170
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.155
DO  - 10.2991/artres.k.191224.155
ID  - Pascaner2020
ER  -

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