Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S169 - S169

P128 Accuracy of Age-appropriate Transfer Functions in Modelling Central Arterial Waveform Features

Authors
Tommy Cai1, 2, *, Meroni Alice1, Ahmad Qasem3, 4, Mark Butlin3, Julian Ayer5, 1, David Celermajer2, 1, Alberto Avolio3, Michael Skilton1
1University of Sydney, Sydney, Australia
2Royal Prince Alfred Hospital, Sydney, Australia
3Macquarie University, Sydney, Australia
4AtCor Medical, Sydney, Australia
5The Children’s Hospital at Westmead, Sydney, Australia
*Corresponding author. Email: ycai2030@uni.sydney.edu.au
Corresponding Author
Tommy Cai
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.154How to use a DOI?
Abstract

Background: Central aortic pressure waveforms can be modelled non-invasively in adults using general transfer functions. These techniques have been applied to, but not formally validated in paediatric populations. We recently developed and validated two age-appropriate paediatric transfer functions and sought to determine their effectiveness in children and adolescents.

Methods: We recruited 97 healthy children between 2 and 20 years of age in five pre-specified age groups. Central waveforms were estimated by applying two previously developed paediatric transfer functions developed in 8 year and 14 year-old children (8TF, 14TF respectively), and a proprietary adult transfer function (aTF) (Sphygmocor CvMS, AtCor) to radial waveforms measured by tonometry [1]. Estimated central arterial parameters were measured from direct carotid tonometry.

Results: 8TF estimates higher cSBP than 14TF, which estimates higher cSBP than aTF across all ages. In contrast, 8TF estimates lower cAIx than 14TF, which estimates lower cAIx than aTF across all ages (Figure 1). 8TF most accurately modelled central arterial waveform features, specifically by cAIx when comparing to carotid tonometry, in early childhood (age groups: 2–6.5 years, 0 ± 14%; 6.6–9.5 years, − 4 ± 19%; 9.6–12.5 years, −6 ± 13%), while 14TF most accurately estimated cAIx in later childhood and adolescence (12.6–15.5 years, −3 ± 11%; 15.6–20 years, 4 ± 13%).

Conclusion: Effectiveness of transfer functions for modelling central arterial waveforms in childhood appear to be age-dependent, with evidence of better accuracy when used in populations similar to that in which they were developed. These results support the use of multiple age-appropriate paediatric transfer functions over a generalized paediatric transfer function.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Reference

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Download article (PDF)
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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S169 - S169
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.154How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Tommy Cai
AU  - Meroni Alice
AU  - Ahmad Qasem
AU  - Mark Butlin
AU  - Julian Ayer
AU  - David Celermajer
AU  - Alberto Avolio
AU  - Michael Skilton
PY  - 2020
DA  - 2020/02/17
TI  - P128 Accuracy of Age-appropriate Transfer Functions in Modelling Central Arterial Waveform Features
JO  - Artery Research
SP  - S169
EP  - S169
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.154
DO  - 10.2991/artres.k.191224.154
ID  - Cai2020
ER  -