P80 Predictors of Middle Cerebral Artery Pulsatility Index in Chronic Obstructive Pulmonary Disease and Healthy Controls; Data from the ACRADE Study

Mahfoudha Al Shezawi; Maggie Munnery; John Cockcroft; Laura Watkeys; Eric Stohr; Nichola Gale; Barry McDonnell

doi:10.2991/artres.k.191224.110

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Volume 25, Issue Supplement 1, December 2019, Pages S123 - S123

P80 Predictors of Middle Cerebral Artery Pulsatility Index in Chronic Obstructive Pulmonary Disease and Healthy Controls; Data from the ACRADE Study

Authors

Mahfoudha Al Shezawi¹^{, 2}^{, *}, Maggie Munnery², John Cockcroft², Laura Watkeys², Eric Stohr², Nichola Gale¹, Barry McDonnell²

¹Cardif University, Cardiff, UK

²Cardiff Metropolitan University, Cardiff, UK

^*Corresponding author. Email: alshezawimm1@cardiff.ac.uk

Corresponding Author

Mahfoudha Al Shezawi

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.110 How to use a DOI?
Abstract: Background: Chronic obstructive pulmonary disease (COPD) is characterised by airway limitation which is an independent predictor of increased cardiovascular (CV) risk and mortality [1]. COPD is associated with increased arterial stiffness [2] and increased incidence of all stroke subtypes [3]. However, the mechanism linking this association is not fully understood. The study aims to identify predictors of middle cerebral artery pulsatility (MCAPI) in COPD and controls.

Method: MCAPI was measured using transcranial Doppler ultrasound. Aortic pulse wave velocity (aPWV) and central pulse pressure (CPP) were measured using the SphygmoCor system. Forced expiratory volume in the first second/forced vital capacity (FEV1/FVC) was measured using spirometry. Use of CV acting medications were recorded.

Result: 45 COPD patients and 50 healthy controls were included in the analyses. Age, gender, CPP and MCAPI were similar between groups, however the COPD patients showed higher aPWV, lower FEV1/FVC and were on more CV acting medication (all, p < 0.05). In COPD, MCAPI was significantly associated with CPP (r = 0.433, p = 0.003) and FEV1/FVC (r = 0.330, p = 0.027), but not aPWV. In controls, MCAPI was significantly associated with CPP (r = 0.601, p = 0.001) and aPWV (r = 0.452, p = 0.001). However, Stepwise Multiple Regression Analysis illustrated that only CPP remained an independent predictor of MCAPI (p = 0.003), in a model which included age, aPWV, FEV1/FVC and use of CV acting medications.

Conclusion: Within the COPD group, CPP was independently associated with MCAPI, even when accounting for use of CV acting medications. However, the interaction between CV acting medications and the relationship between aPWV and MCAPI remains unclear and needs further investigations.
Copyright: © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]M Duong, S Islam, S Rangarajan, D Leong, O Kurmi, K Teo, et al., Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1 (PURE): an international, community-based cohort study, Lancet Glob Health, Vol. 7, 2019, pp. e613-e23.

[2]M Söderholm, M Inghammar, B Hedblad, A Egesten, and G Engström, Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease, Eur J Epidemiol, Vol. 31, 2016, pp. 159-68.

[3]NL Mills, JJ Miller, A Anand, SD Robinson, GA Frazer, D Anderson, et al., Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk, Thorax, Vol. 63, 2008, pp. 306-11.

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S123 - S123
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.110 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Mahfoudha Al Shezawi
AU  - Maggie Munnery
AU  - John Cockcroft
AU  - Laura Watkeys
AU  - Eric Stohr
AU  - Nichola Gale
AU  - Barry McDonnell
PY  - 2020
DA  - 2020/02/17
TI  - P80 Predictors of Middle Cerebral Artery Pulsatility Index in Chronic Obstructive Pulmonary Disease and Healthy Controls; Data from the ACRADE Study
JO  - Artery Research
SP  - S123
EP  - S123
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.110
DO  - 10.2991/artres.k.191224.110
ID  - AlShezawi2020
ER  -

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