P114 “Stifflammation” is an Essential Cause of Cardiovascular Hospitalizations in Hypertensives

DOI

10.2991/artres.k.191224.140How to use a DOI?

Abstract

Purpose/Background/Objectives: Hypertension is associated with increased cardiovascular risk, inflammation and arterial stiffness. We sought to investigate the role of inflammation and arterial stiffness in the prognosis of cardiovascular hospitalization in hypertensives patients over an extensive follow-up.

Methods: One hundred and seventy-three patients (mean age 52.5 ± 13.2 years, 57% males) untreated hypertensives at baseline without cardiovascular disease, were included in the study. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (PWV). High-sensitivity C-reactive protein (hsCRP) was measured in venous blood samples.

Results: During 13.6 ± 0.4 years of follow-up, forty-four patients (25.4%) patients were admitted in hospital due to cardiovascular causes. In multivariable logistic regression analysis, only higher hsCRP (Odds Ratio [OR] = 3.34, 95% Confidence intervals [CI]: 1.22–9.51, p = 0.020) and increased PWV (OR = 1.48, 95% Confidence intervals [CI]: 1.03–2.12, p = 0.036) were associated with higher risk of cardiovascular hospitalizations, which was independent of age, gender, systolic blood pressure, left ventricular mass index and presence of diabetes. In further analysis, receiver operating characteristic (ROC) curves were generated to evaluate the ability of hsCRP and PWV to discriminate subjects with cardiovascular hospitalization. The area under the curve (AUC) and 95% CIs of the ROC curves were AUC = 0.69 (95% CI: 0.59–0.78, p < 0.001) for hsCRP and AUC = 0.74 (95% CI: 0.65–0.83, p < 0.001) for PWV (Figure 1).

Figure 1

Diagonal segments are produced by ties.

Conclusion: Our study shows the independent complimentary prognostic role of inflammation and arterial stiffness in the prognosis of hypertensives even in studies with extensive follow-up.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

TY  - JOUR
AU  - Georgia Christopoulou
AU  - Charalambos Vlachopoulos
AU  - Lambros Korogiannis
AU  - Dimitrios Terentes-Printzios
AU  - Evangelia Sigala
AU  - Iosif Koutagiar
AU  - Vasiliki Gardikioti
AU  - Dimitrios Tousoulis
PY  - 2020
DA  - 2020/02/17
TI  - P114 “Stifflammation” is an Essential Cause of Cardiovascular Hospitalizations in Hypertensives
JO  - Artery Research
SP  - S154
EP  - S154
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.140
DO  - 10.2991/artres.k.191224.140
ID  - Christopoulou2020
ER  -