P82 Impaired Skin Microvascular Function in Systemic Lupus Erythematosus

Nikolaos Koletsos; Eugenia Gkaliagkousi; Antonios Lazaridis; Panagiota Anyfanti; Areti Triantafyllou; Konstantina Dipla; Panagiotis Dolgyras; Vasiliki Galanopoulou; Spyros Aslanidis; Stella Douma

doi:10.2991/artres.k.191224.112

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Volume 25, Issue Supplement 1, December 2019, Pages S125 - S125

P82 Impaired Skin Microvascular Function in Systemic Lupus Erythematosus

Authors

Nikolaos Koletsos¹^{, *}, Eugenia Gkaliagkousi¹, Antonios Lazaridis¹, Panagiota Anyfanti¹, Areti Triantafyllou¹, Konstantina Dipla², Panagiotis Dolgyras¹, Vasiliki Galanopoulou³, Spyros Aslanidis⁴, Stella Douma¹

¹3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

²Exercise Physiology and Biochemistry Laboratory, Department of Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece

³Rheumatology Department, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

⁴Rheumatology Department-2nd Propedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

^*Corresponding author. Email: nick.koletsos@gmail.com

Corresponding Author

Nikolaos Koletsos

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.112 How to use a DOI?
Abstract: Objectives: Alterations in skin microcirculation have been associated with damage in various microvascular beds [1]. Endothelial dysfunction in microcirculation plays a central role in the pathophysiology of rheumatic diseases, contributing substantially to the increased cardiovascular risk of these patients. Laser speckle contrast analysis (LASCA) is a novel non-invasive technique that can be used to evaluate endothelial function of skin microcirculation [2]. Previous studies have shown impaired skin endothelial function in patients with systemic sclerosis. To our knowledge, no previous study has evaluated skin microcirculation in patients with SLE using LASCA [3,4].

Design and Methods: Fifty-two individuals (25 SLE patients and 27 matched controls) were studied. In all subjects, forearm skin blood flow was recorded under standardized conditions using a laser speckle contrast imager (PeriCam PSI NR System, Perimed). Post-occlusive reactive hyperemia (PORH) was assessed following a standardized protocol and data were analyzed with signal processing software (PIMSoft, Perimed). The amplitude of PORH responses was expressed as a percentage increase between peak and baseline perfusion (%).

Results: There were no differences among the two groups in age, sex, body mass index and hypertension status. Post occlusion reperfusion in SLE patients, was significantly lower as compared to non-SLE controls (155.5 ± 53.1 vs 194.5 ± 40.5% respectively, p = 0.004).

Conclusion: Patients with SLE demonstrate impaired skin microvascular endothelial function, providing a link that could explain the increased cardiovascular risk that these patients bear.
Copyright: © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]TT Nguyen, JE Shaw, C Robinson, R Kawasaki, JJ Wang, AJ Kreis, et al., Diabetic retinopathy is related to both endothelium-dependent and -independent responses of skin microvascular flow, Diabetes Care, Vol. 34, 2011, pp. 1389-93.

[2]M Roustit and JL Cracowski, Assessment of endothelial and neurovascular function in human skin microcirculation, Trends Pharmacol Sci, Vol. 34, 2013, pp. 373-84.

[3]B Ruaro, A Sulli, E Alessandri, C Pizzorni, G Ferrari, and M Cutolo, Laser speckle contrast analysis: a new method to evaluate peripheral blood perfusion in systemic sclerosis patients, Ann Rheum Dis, Vol. 73, 2014, pp. 1181-5.

[4]A Della Rossa, M Cazzato, A d'Ascanio, A Tavoni, W Bencivelli, P Pepe, et al., Alteration of microcirculation is a hallmark of very early systemic sclerosis patients: a laser speckle contrast analysis, Clin Exp Rheumatol, Vol. 31, 2013, pp. S109-S14.

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S125 - S125
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.112 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Nikolaos Koletsos
AU  - Eugenia Gkaliagkousi
AU  - Antonios Lazaridis
AU  - Panagiota Anyfanti
AU  - Areti Triantafyllou
AU  - Konstantina Dipla
AU  - Panagiotis Dolgyras
AU  - Vasiliki Galanopoulou
AU  - Spyros Aslanidis
AU  - Stella Douma
PY  - 2020
DA  - 2020/02/17
TI  - P82 Impaired Skin Microvascular Function in Systemic Lupus Erythematosus
JO  - Artery Research
SP  - S125
EP  - S125
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.112
DO  - 10.2991/artres.k.191224.112
ID  - Koletsos2020
ER  -

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