Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S125 - S125

P82 Impaired Skin Microvascular Function in Systemic Lupus Erythematosus

Authors
Nikolaos Koletsos1, *, Eugenia Gkaliagkousi1, Antonios Lazaridis1, Panagiota Anyfanti1, Areti Triantafyllou1, Konstantina Dipla2, Panagiotis Dolgyras1, Vasiliki Galanopoulou3, Spyros Aslanidis4, Stella Douma1
13rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
2Exercise Physiology and Biochemistry Laboratory, Department of Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece
3Rheumatology Department, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
4Rheumatology Department-2nd Propedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
*Corresponding author. Email: nick.koletsos@gmail.com
Corresponding Author
Nikolaos Koletsos
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.112How to use a DOI?
Abstract

Objectives: Alterations in skin microcirculation have been associated with damage in various microvascular beds [1]. Endothelial dysfunction in microcirculation plays a central role in the pathophysiology of rheumatic diseases, contributing substantially to the increased cardiovascular risk of these patients. Laser speckle contrast analysis (LASCA) is a novel non-invasive technique that can be used to evaluate endothelial function of skin microcirculation [2]. Previous studies have shown impaired skin endothelial function in patients with systemic sclerosis. To our knowledge, no previous study has evaluated skin microcirculation in patients with SLE using LASCA [3,4].

Design and Methods: Fifty-two individuals (25 SLE patients and 27 matched controls) were studied. In all subjects, forearm skin blood flow was recorded under standardized conditions using a laser speckle contrast imager (PeriCam PSI NR System, Perimed). Post-occlusive reactive hyperemia (PORH) was assessed following a standardized protocol and data were analyzed with signal processing software (PIMSoft, Perimed). The amplitude of PORH responses was expressed as a percentage increase between peak and baseline perfusion (%).

Results: There were no differences among the two groups in age, sex, body mass index and hypertension status. Post occlusion reperfusion in SLE patients, was significantly lower as compared to non-SLE controls (155.5 ± 53.1 vs 194.5 ± 40.5% respectively, p = 0.004).

Conclusion: Patients with SLE demonstrate impaired skin microvascular endothelial function, providing a link that could explain the increased cardiovascular risk that these patients bear.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S125 - S125
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.112How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Nikolaos Koletsos
AU  - Eugenia Gkaliagkousi
AU  - Antonios Lazaridis
AU  - Panagiota Anyfanti
AU  - Areti Triantafyllou
AU  - Konstantina Dipla
AU  - Panagiotis Dolgyras
AU  - Vasiliki Galanopoulou
AU  - Spyros Aslanidis
AU  - Stella Douma
PY  - 2020
DA  - 2020/02/17
TI  - P82 Impaired Skin Microvascular Function in Systemic Lupus Erythematosus
JO  - Artery Research
SP  - S125
EP  - S125
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.112
DO  - 10.2991/artres.k.191224.112
ID  - Koletsos2020
ER  -