Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S158 - S158

P118 Arterial Stiffness in Patients with Arterial Hypertension on Short Term Dual Treatment with Fimasartan/Amlodipine

Authors
Brandon Giovany Illescas Vidrio*, David Cardona Müller, Ernesto Germán Cardona Muñoz, Claudia Yanette Gálan Ruiz, Carlos Gerardo Ramos Becerra, Fernando Grover Páez
Laboratorio de Mecánica Vascular, Universidad de Guadalajara, Guadalajara, Mexico
*Corresponding author. Email: brandonillescas@outlook.com
Corresponding Author
Brandon Giovany Illescas Vidrio
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.144How to use a DOI?
Abstract

Background: Pulse wave velocity (PWV) reflects arterial stiffness and is an independent predictor of cardiovascular mortality and morbidity. It is important to determine the effect dual therapy has on both BP and PWV.

Methods: A quasi-experimental study was performed in patients with grade 1 and 2 primary hypertension (HTN). Patients received the combination amlodipine/fimasartan (5 mg/60 mg/day) for 8 weeks. Anthropometric and hemodynamic measurements were made after a 2-week washout period and at week 8 of treatment. The brachial-ankle pulse wave velocity (baPWV), SBP, DBP, Pulse pressure (PP), central systolic blood pressure (cSBP) and the augmentation index normalized to 75 bpm (pAIx75) were measured.

Results: We included 42 patients (14 women) aged 56 ± 16 years. We observed a decrease in baVOP, 17.99 ± 2.80 m/s vs 16.14 ± 2.36 m/s, (p < 0.001); SBP 160 ± 18 mmHg vs 138 ± 14 mmHg (p < 0.001); DBP 96 ± 14 mmHg vs 82 ± 10 mmHg, (p < 0.001); PP 63 ± 18 mmHg vs 56 ± 14 mmHg, (p < 0.001); AIx75 85 ± 9% vs 80 ± 10%, (p = 0.002); and cSBP 151 ± 18 mmHg vs 128 ± 15 mmHg (p < 0.001). Before the treatment 71% patients had arterial stiffness and after the treatment only 33% of the patients had it, the BP goal of < 130/80 was achieved in only 16%.

Conclusion: The short term dual therapy with amlodipine/fimasartan significantly decreased baPWV, cSBP, PP, SBP, DBP and pAIx75. Only 16% of the patients achieved the BP goal with this treatment.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]M Munakata, Brachial-ankle pulse wave velocity: background, method, and clinical evidence, Pulse, Vol. 3, 2015, pp. 195-204.
[2]R Shi, K Liu, D Shi, Q Liu, and X Chen, Effects of amlodipine and valsartan on blood pressure variability and pulse wave velocity in hypertensive patients, Am J Med Sci, Vol. 353, 2017, pp. 6-11.
<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S158 - S158
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.144How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Brandon Giovany Illescas Vidrio
AU  - David Cardona Müller
AU  - Ernesto Germán Cardona Muñoz
AU  - Claudia Yanette Gálan Ruiz
AU  - Carlos Gerardo Ramos Becerra
AU  - Fernando Grover Páez
PY  - 2020
DA  - 2020/02/17
TI  - P118 Arterial Stiffness in Patients with Arterial Hypertension on Short Term Dual Treatment with Fimasartan/Amlodipine
JO  - Artery Research
SP  - S158
EP  - S158
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.144
DO  - 10.2991/artres.k.191224.144
ID  - IllescasVidrio2020
ER  -