P117 Case Report of a Patient with Extreme Reverse Dipping Phenomenon Decades After Kidney Transplantation

DOI

10.2991/artres.k.191224.143How to use a DOI?

Abstract

A patient with the complaint of moderately elevated blood pressure came to our office. Important data in his history was kidney transplantation in 1985, due to glomerulonephritis and since that time he was in regular nephrology care. He also had chronic lumboischialgia, chronic hypertension and stage 3b chronic kidney disease. He was included into our screening program, in which arterial stiffness and central hemodynamics were also registered with Mobil-O-Graph. Besides moderately elevated office blood pressure (143/102 mmHg, heart rate: 68/min), in ABPM extreme reverse dipping phenomenon (24 h average: 140/93 mmHg; daytime average: 130/86 mmHg; night-time average: 175/114 mmHg) was found, which was unknown until that time. The blood pressure elevation appeared immediately in supine position. Antihypertensive medications were modified. Ultrasound of the transplanted kidney did not confirm compression of the renal artery; on ECHO left ventricular hypertrophy was found. Neuropathy test described autonomic neuropathy. After the modification of antihypertensive medications, the extreme reverse dipping phenomenon was attenuated, but still present. Benfotiamine + Pyridoxine (200/200 mg daily) was started by a rheumatologist, because of chronic back pain. After a year of their administration in an ABPM control the neuroprotective medication was ineffective for the recovery of the extreme reverse dipping phenomenon, but 19 months following the initiation, the supine hypertension phenomenon was further attenuated. In conclusions, in patients decades after kidney transplantation autonomic neuropathy can lead to supine hypertension and extreme reverse dipping phenomenon on ABPM, which can be influenced with the modification of antihypertensive medications and probably with neuroprotective agents.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

TY  - JOUR
AU  - Dóra Batta
AU  - Beáta Kőrösi
AU  - Zsófia Nemcsik-Bencze
AU  - János Nemcsik
PY  - 2020
DA  - 2020/02/17
TI  - P117 Case Report of a Patient with Extreme Reverse Dipping Phenomenon Decades After Kidney Transplantation
JO  - Artery Research
SP  - S157
EP  - S157
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.143
DO  - 10.2991/artres.k.191224.143
ID  - Batta2020
ER  -