P69 The Initial Upstroke Time is Most Strongly Associated with the Severity of as Among Brachial Pulse Wave Parameters

Masao Takahashi; Kyohei Fukatani; Tomoyuki Kabutoya; Satoshi Hoshide; Tatsuya Yoneyama; Tetsuya Ito; Kazuomi Kario

doi:10.2991/artres.k.191224.100

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Volume 25, Issue Supplement 1, December 2019, Pages S113 - S113

P69 The Initial Upstroke Time is Most Strongly Associated with the Severity of as Among Brachial Pulse Wave Parameters

Authors

Masao Takahashi¹^{, *}, Kyohei Fukatani², Tomoyuki Kabutoya³, Satoshi Hoshide³, Tatsuya Yoneyama⁴, Tetsuya Ito², Kazuomi Kario³

¹Department of Cardiovascular Medicine, Jichi Medical University, Shimotsuke, Japan

²Academic Promotion Section, Fukuda Denshi Co., Ltd.

³Jichi Medical University, Japan

⁴R&D Head Office, Fukuda Denshi Co., Ltd.

^*Corresponding author. Email: md32144@gmail.com

Corresponding Author

Masao Takahashi

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.100 How to use a DOI?
Abstract: Background: Aortic valve stenosis (AS) is the most common valve disease in an elderly population, therefore, simple screening examination for AS is needed. Although a prolonged carotid upstroke time (UT), and prolonged ejection time (ET) of a brachial pulse wave (BPW) have been observed in severe AS patients, it has been unclear which BPW parameters have a better correlation with the severity of AS. The aim of this study was to examine which BPW parameters are most relevant to the severity of AS.

Methods: Sixty-five Consecutive moderate and severe AS patients who were evaluated by trans-thoracic echocardiography were enrolled in this study. Control patients who were adjusted for age, gender, and blood pressure among outpatients were enrolled (N = 110). UT, ET, initial upstroke time (iUT), and half rise time of upstroke (1/2 hrUT) were evaluated correlations between mean pressure gradient (mPG) among AS patients.

Results: iUT and 1/2 hrUT have significant correlations with mPG among AS patients (iUT: R = 0.50, 95% CI = 0.29–0.67, p < 0.0001; 1/2 hrUT: R = 0.41, 95% CI = 0.19–0.60, p < 0.001), whereas UT and ET did not. Multivariate logistic regression analysis showed area under curve (AUC) of iUT and 1/2 hrUT were higher than UT and ET to predict mPG >40 mmHg (AUC: iUT vs 1/2 hrUT vs UT vs ET = 0.90 vs 0.89 vs 0.69 vs 0.77).

Conclusion: The severity of AS appeared strongly in the first half of the BPW upstroke. iUT and 1/2 hrUT may be a simple and useful screening test to assess the severity of AS.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S113 - S113
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.100 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Masao Takahashi
AU  - Kyohei Fukatani
AU  - Tomoyuki Kabutoya
AU  - Satoshi Hoshide
AU  - Tatsuya Yoneyama
AU  - Tetsuya Ito
AU  - Kazuomi Kario
PY  - 2020
DA  - 2020/02/17
TI  - P69 The Initial Upstroke Time is Most Strongly Associated with the Severity of as Among Brachial Pulse Wave Parameters
JO  - Artery Research
SP  - S113
EP  - S113
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.100
DO  - 10.2991/artres.k.191224.100
ID  - Takahashi2020
ER  -

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