Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S66 - S66

P23 Tadalafil improves hemodynamic parameters and arterial stiffness in patients with grade I-II obesity without comorbidities

Authors
Mariana Larios-Cardenas*, Fernando Grover-Páez, David Cardona-Muller, Ernesto Cardona, Oscar I. Gonzalez-Radillo, Jonathan Trujillo-Quiros, Marycruz Barocio-Pantoja, Patricia Quezada-Fernandez, Carlos G. Ramos-Becerra
Physiology Department, University Health Sciences Center, University of Guadalajara, Mexico
*Corresponding author. Email: mariana_larios_cardenas@hotmail.com
Corresponding Author
Mariana Larios-Cardenas
Available Online 15 February 2020.
DOI
10.2991/artres.k.191224.057How to use a DOI?
Abstract

Background: Obesity is a global health problem, it is associated with diabetes, hypertension, and cardiovascular diseases [1] and negative hemodynamic effects have been observed [2]. Tadalafil has shown an improvement in endothelial function [3] the aim of the present investigation was to evaluate its effects on hemodynamic parameters in patients with grade I-II obesity.

Objective: To evaluate the acute effect of tadalafil on hemodynamic and arterial stiffness parameters.

Methods: A double blind clinical trial, randomized, was carried out in patients with grade I-II obesity. Seventy patients were allocated to receive placebo or a single dose of 20 mg of tadalafil; hemodynamic (Omron HEM 9000, UNEXEF) and arterial stiffness (Omrom VP1000) parameters were determined before and 24 hours after intervention. The values are expressed in mean ± SD. Wilcoxon rank test and U de Mann-Whitney were applied. p < 0.05 was considerated as statistically significant.

Results: Both groups were comparable in the baseline. After the intervention a statistically significant changes were shown in the tadalafil group in the diastolic blood pressure (DBP), (.001); second systolic shoulder 2 (SYS2), (.003); augmentation index (Aix), (.049); and braquial-ankle pulse wave velocity (BAPWV), (.005). After that, changes between groups were analyzed and only DBP (−2.39, p = .017) and BAPWV (p = .028) were statistically significant. No changes were observed in flow mediated dilatation (FMD).

Conclusion: Tadalafil modifies DBP and BAPWV but it had not effect on FMD in the acute administration.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[2]ÉA Contreras-Leal and J Santiago-García, Obesidad, síndrome metabólico y su impacto en las enfermedades cardiovasculares, Revista biomédica, Vol. 22, 2011, pp. 103-15.
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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S66 - S66
Publication Date
2020/02/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.057How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Mariana Larios-Cardenas
AU  - Fernando Grover-Páez
AU  - David Cardona-Muller
AU  - Ernesto Cardona
AU  - Oscar I. Gonzalez-Radillo
AU  - Jonathan Trujillo-Quiros
AU  - Marycruz Barocio-Pantoja
AU  - Patricia Quezada-Fernandez
AU  - Carlos G. Ramos-Becerra
PY  - 2020
DA  - 2020/02/15
TI  - P23 Tadalafil improves hemodynamic parameters and arterial stiffness in patients with grade I-II obesity without comorbidities
JO  - Artery Research
SP  - S66
EP  - S66
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.057
DO  - 10.2991/artres.k.191224.057
ID  - Larios-Cardenas2020
ER  -