Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S65 - S65

P22 Central and Peripheral Contributions to Submaximal Exercise Performance in Older Adults in the SouthAll and Brent REvisited (SABRE) Study

Authors
Siana Jones1, *, Martin Schultz2, Therese Tillin1, Suzanne Williams1, Nishi Chaturvedi1, Alun Hughes1
1University College London, London, UK
2Menzies Institute for Medical Research, University of Tasmania, Australia
*Corresponding author. Email: siana.jones@ucl.ac.uk
Corresponding Author
Siana Jones
Available Online 15 February 2020.
DOI
10.2991/artres.k.191224.056How to use a DOI?
Abstract

Background: Functional capacity declines with age leading to disability and increased cost of health and social care. In older adults, factors that influence the ability to sustain sub-maximal exercise (a marker of functional capacity) are not well defined. We aimed to determine the contribution of cardiac function, skeletal muscle oxygen desaturation, extraction and oxidative capacity to sub-maximal exercise performance in a population-based sample of older adults.

Methods: Participants in the SABRE study undertook a 6-minute stepper test (6MST). Sub-maximal exercise performance was assessed as the highest achieved whole-body oxygen uptake (VO2) during the 6MST. Near Infrared Spectroscopy (NIRS) was used to locally assess skeletal muscle oxygen extraction, desaturation and maximum oxidative capacity. Echocardiography was used to measure cardiac function. Analysis was by multiple linear regression adjusted for confounders: age, sex, ethnicity, diabetes and obesity.

Results: 395 participants (73.0 ± 6.3 years old, male; n = 229) undertook the 6MST, skeletal muscle desaturation measurements and echocardiography. Skeletal muscle desaturation and cardiac output were independently associated with whole-body VO2 (standardized β: −0.20, p < 0.001 & 0.47, p < 0.001, respectively). Local skeletal muscle oxygen extraction was independently associated with whole-body VO2 (standardized β adjusted for confounders & cardiac output: 0.32, p < 0.001). Maximum oxidative capacity was not associated with VO2 (β (95% CI: 0.02 (−0.01, 0.04), p = 0.152).

Conclusion: Local oxygen extraction and desaturation in skeletal muscle are independent predictors of sub-maximal exercise performance in older adults. These associations persist with adjustment for cardiac output suggesting local capacity to extract oxygen could be a major limiting factor functional capacity in older adults.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S65 - S65
Publication Date
2020/02/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.056How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Siana Jones
AU  - Martin Schultz
AU  - Therese Tillin
AU  - Suzanne Williams
AU  - Nishi Chaturvedi
AU  - Alun Hughes
PY  - 2020
DA  - 2020/02/15
TI  - P22 Central and Peripheral Contributions to Submaximal Exercise Performance in Older Adults in the SouthAll and Brent REvisited (SABRE) Study
JO  - Artery Research
SP  - S65
EP  - S65
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.056
DO  - 10.2991/artres.k.191224.056
ID  - Jones2020
ER  -