Artery Research

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Volume 24, Issue C, December 2018, Pages 62 - 62

VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS

Authors
Negoita Madalina1, Manisty Charlotte2, Bhuva Anish2, Hughes Alun2, Parker Kim3, Khir Ashraf1
1Brunel Institute of Bioengineering, Brunel University London, UK
2Institute of Cardiovascular Science, University College London, UK
3Department of Bioengineering, Imperial College London, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.005How to use a DOI?
Abstract

Background: Pulse Wave Velocity (PWV) is a measure of arterial stiffness which predicts cardiovascular risk independently of blood pressure. Local PWV can be measured non-invasively in the ascending aorta of adults by means of Ultrasound (US), using successive recordings of Diameter (D) and the velocity (U) [1].

Aim: To test US measurements of local PWV in the ascending aorta of human adults against MRI measurements of local PWV.

Methods: PWV in the ascending aorta of 8 healthy volunteers (age 22–34y, 3 females) was measured using a Siemens MAGNETOM Aera 1.5T MRI scanner as per standard protocols with cine and phase contrast imaging (sampling frequency 100 samples/cardiac cycle) and D and U were calculated using validated software [2]. US images were recorded using GE Vivid E95 scanner with a 1.5–4.5 MHz phased array transducer. PLAX was used for diameter recordings and A5CH for velocity. Measurements were recorded for 20s during a breath-hold. D and U waveforms were extracted from each imaging modality to calculate PWV using the ln(D)U-loops technique [3].

Results: Average results are summarised in Table 1. The mean difference in PWV between MRI and US was 2.8 ± 0.3%.

Conclusions: PWV measured by US shows excellent agreement with MRI in the ascending aorta of adults. Given US availability, this technique offers an easy, affordable and non-invasive means of determining PWV and mechanical properties of the ascending aorta; thus, providing a tool for screening studies.

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This is an open access article distributed under the CC BY-NC license.

References

1.Madalina Negoita, Alun D Hughes, Kim H Parker, and Ashraf W Khir, Non-invasive Technique for Determining Local Pulse Wave Velocity in Humans Ascending Aorta, Computing in Cardiology, Vol. 44, 2017, pp. 1-4.
2.A De Cesare, A Redheuil, A Dogui, O Jolivet, A Lalande, F Frouin, E Mousseaux, and A Herment, ART-FUN: an Integrated Software for Functional Analysis of the Aorta, Journal of Cardiovascular Magnetic Resonance, Vol. 11, No. Suppll 1, 2009, pp. P182.
3.J Feng and AW Khir, Determination of wave speed and wave separation in the arteries using diameter and velocity, Journal of Biomechanics, Vol. 43, No. 3, 2010, pp. 455-462.
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Journal
Artery Research
Volume-Issue
24 - C
Pages
62 - 62
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.005How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Negoita Madalina
AU  - Manisty Charlotte
AU  - Bhuva Anish
AU  - Hughes Alun
AU  - Parker Kim
AU  - Khir Ashraf
PY  - 2018
DA  - 2018/12/04
TI  - VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS
JO  - Artery Research
SP  - 62
EP  - 62
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.005
DO  - 10.1016/j.artres.2018.10.005
ID  - Madalina2018
ER  -