P8.8 CENTRAL ARTERIAL STIFFNESS IN COPD

DOI

10.1016/j.artres.2015.10.330How to use a DOI?

Abstract

Introduction: Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function.

Methods: As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined.

Results: Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP^* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP^* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r=0.39) and controls (r=0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2=33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2=37%, p<0.001).

Conclusion: Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Ali Albarrati*
AU  - Nichola Gale
AU  - Maggie Munnery
AU  - Sujoy Saikia
AU  - Dennis Shale
AU  - John Cockcroft
PY  - 2015
DA  - 2015/11/23
TI  - P8.8 CENTRAL ARTERIAL STIFFNESS IN COPD
JO  - Artery Research
SP  - 36
EP  - 36
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.330
DO  - 10.1016/j.artres.2015.10.330
ID  - Albarrati*2015
ER  -