P185 CARDIO-ANKLE VASCULAR INDEX AND PLASMA LEVELS OF LEPTIN AND ADIPONECTIN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
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- Abstract
Objective: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with vascular derangement [1]. Leptin and adiponectin are adipokines with immunomodulatory and vascular functions [2]. We studied the association between arterial stiffness and plasma leptin and adiponectin levels in SLE patients in Ghana.
Methods: In a case control design involving 80 SLE patients and 90 non-SLE controls, arterial stiffness was assessed by cardio-ankle vascular index (CAVI) and heart-ankle pulse wave velocity (haPWV) using Vasera 1500N. Circulating levels of leptin, adiponectin, insulin and C-reactive protein (CRP) were measured by ELISA.
Results: Compared to non-SLE controls, SLE patients had higher levels of CAVI (7.3±1.1 vs 6.1±1, p < 0.001), haPWV (7.7±1.3 vs 6.5±0.8 m/s, p = <0.001), insulin [76.8 (45.9–184.8) vs 39.8 (22.9–86.3) pmol/ml, p = 0.007], leptin [856.1 (364.8–1509.3) vs 426.7 (426.8 (84.7–1178.7) ng/ml, p = 0.039], adiponectin [1.1 (0.8–2.3) vs 1.6 (1.3–2.6) ng/ml, p = 0.039] and CRP [1.6 (0.8–2.2) vs 0.9 (0.6–1.2) mg/ml, p = 0.021]. In a partial correlation analysis with adjustment for age and BMI, CAVI was associated with leptin (r = 0.21, p = 0.031), CRP (r = 2.9, p < 0.001) and insulin (r = 0.18, p = 0.04), but not adiponectin (r = −0.15, p = 0.068).
Conclusion: In our study population, SLE patients have higher arterial stiffness, associated with low-grade inflammation and deranged circulating adipokine levels.
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TY - JOUR AU - Kwame Yeboah AU - Richard NA. Owusu Mensah AU - Dzifa Dey AU - Vincent Boima AU - J. Kennedy Cruickshank PY - 2017 DA - 2017/12/06 TI - P185 CARDIO-ANKLE VASCULAR INDEX AND PLASMA LEVELS OF LEPTIN AND ADIPONECTIN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS JO - Artery Research SP - 106 EP - 107 VL - 20 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2017.10.186 DO - 10.1016/j.artres.2017.10.186 ID - Yeboah2017 ER -