Artery Research

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Volume 20, Issue C, December 2017, Pages 107 - 107

P186 IMPACT OF OBESITY ON VASCULAR STRUCTURE AND FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS

Authors
Thessa Hilgenkamp1, 2, Garett Griffith2, Robert Motl3, 4, Tracy Baynard2, Bo Fernhall2
1Erasmus MC University Medical Center Rotterdam, The Netherlands
2Integrative Physiology Laboratory, University of Illinois at Chicago, USA
3Department of Physical Therapy, University of Alabama at Birmingham, USA
4University of Alabama at Birmingham/Lakeshore Research Collaborative, USA
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.187How to use a DOI?
Abstract

Background: Cardiovascular disease is a leading cause of disease progression and death in multiple sclerosis (MS). Obesity has a negative impact on vascular structure and function, but whether this contributes to worse vascular function similarly in individuals with MS and controls is unknown.

Aim: To investigate the impact of obesity on vascular function and structure in a group with MS.

Methods: In a sample of n = 133 participants (MS: n = 89, control n = 44), height and weight were measured to calculate BMI. After a 10 minute rest in the supine position, resting heart rate (HR) and brachial blood pressure (BP) were collected. Augmentation index (AIX), HR normalized AIX (AIX@HR75) and pulse wave velocity (PWV) and subendocardial viability ratio (SEVR) were measured with applanation tonometry.

Carotid intima-media thickness (IMT) and beta-stiffness (beta) were measured with carotid ultrasound, and Forearm Blood Flow (FBF Baseline, Peak and Area Under the Curve (AUC)) was measured with strain gauge plethysmography. Data were analyzed with multiple linear regression analyses with group, sex, BMI and GroupxBMI as independent variables.

Results: Higher BMI correlated with higher HR and PWV in both groups. In the MS group however, a higher BMI was also correlated with worse outcomes on the SEVR, FBF Baseline, Peak and AUC.

Outcome variables Standardized beta1 Adjusted R2
Group Sex BMI Grp x BMI
HR rest 1.081* 0.005 0.520* −0.944 0.11
AIX −0.019 −0.523* 0.040 0.045 0.26
AIX@HR75 0.341 −0.536* 0.235 −0.270 0.32
SEVR −1.292* 0.175* −0.565* 1.090* 0.22
PWVc 0.001 −0.003 0.321* 0.120 0.12
PWVc/MAP 0.324 −0.126 0.278 −0.122 0.11
IMT 0.715 0.164 0.385 −0.511 0.12
FBF Baseline 0.432 0.070 0.326* −1.090* 0.33
FBF Peak 0.580 0.318* 0.152 −1.035* 0.35
FBF AUC 0.746 0.230* 0.316 −1.174* 0.21
1

Group (0 = control, 1 = multiple sclerosis), Sex (1 = Female, 2 = Male).

*

(p < 0.05).

Conclusions: Having a higher BMI contributes even more to a worse vascular profile in MS patients than in controls, suggesting that reducing overweight and obesity in the MS population will benefit their vascular structure and function.

Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
107 - 107
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.187How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Thessa Hilgenkamp
AU  - Garett Griffith
AU  - Robert Motl
AU  - Tracy Baynard
AU  - Bo Fernhall
PY  - 2017
DA  - 2017/12/06
TI  - P186 IMPACT OF OBESITY ON VASCULAR STRUCTURE AND FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS
JO  - Artery Research
SP  - 107
EP  - 107
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.187
DO  - 10.1016/j.artres.2017.10.187
ID  - Hilgenkamp2017
ER  -