Artery Research

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Volume 20, Issue C, December 2017, Pages 104 - 104

P157 RETINAL ARTERIOLAR FUNCTION, ENDOTHELIAL DYSFUNCTION AND ARTERIAL STIFFNESS IN PATIENTS WITH TYPE 2 DIABETES

Authors
Jonathan Baier1, 2, Søren Tang Knudsen2, Line Petersen3, Kristian Løkke Funck1, 2, Liv Vernstrøm Hald1, 2, Toke Bek3, Per Løgstrup Poulsen1, 2, Esben Laugesen2
1Aarhus University, Aarhus, Denmark
2Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark
3Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.178How to use a DOI?
Abstract

Background: Crosstalk between large and small arteries has been suggested to partake in the microvascular complication development in patients with type 2 diabetes mellitus (T2DM). Yet, data are scarce.

In the present study, we aimed to elucidate the crosstalk between large and small arteries in T2DM.

Methods: Twenty patients with T2DM and 20 sex- and age matched controls were included. Arterial stiffness was assessed by carotid-femoral Pulse Wave Velocity (cfPWV) using the SphygmoCor. Endothelial function was assessed using EndoPAT. Retinal blood supply regulation was examined by retinal arteriolar diameter change during i) exposure to flickering lights, ii) isometric exercise (hand-weight lifting), and iii) a combined stimulus of i) + ii) using the Retinal Vessel Analyzer (RVA).

Results: T2DM patients had higher cfPWV than controls (9.3±1.8 m/s vs. 8.3±2.2 m/s, p = .049). No group difference was observed in endothelial function (0.71±0.30 vs. 0.81±0.30, p = .32) or in response to intervention with flicker, exercise or the combination (all p > 0.05). Endothelial function was associated with mean arteriolar diameter change for the combination intervention (Beta = 0.033 [0.0013; 0.064], p = .042) in patients and controls. No association was observed between cfPWV and retinal arteriolar %-diameter change in patients or controls.

Conclusion: Peripheral endothelial function was associated with retinal arteriolar diameter change. Our findings may indicate a contribution of macro-microvascular crosstalk in diabetes complication development.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
104 - 104
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.178How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Jonathan Baier
AU  - Søren Tang Knudsen
AU  - Line Petersen
AU  - Kristian Løkke Funck
AU  - Liv Vernstrøm Hald
AU  - Toke Bek
AU  - Per Løgstrup Poulsen
AU  - Esben Laugesen
PY  - 2017
DA  - 2017/12/06
TI  - P157 RETINAL ARTERIOLAR FUNCTION, ENDOTHELIAL DYSFUNCTION AND ARTERIAL STIFFNESS IN PATIENTS WITH TYPE 2 DIABETES
JO  - Artery Research
SP  - 104
EP  - 104
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.178
DO  - 10.1016/j.artres.2017.10.178
ID  - Baier2017
ER  -