P158 ASSOCIATION BETWEEN AMBULATORY ARTERIAL STIFFNESS INDEX, MARKERS OF BLOOD PRESSURE VARIABILITY AND INDICES OF SUBCLINICAL VASCULAR DAMAGE IN OBESE CHILDREN

DOI

10.1016/j.artres.2017.10.179How to use a DOI?

Abstract

Objective: Ambulatory Arterial Stiffness Index (AASI) and symmetric AASI (sAASI) have been proposed as indices of arterial stiffness obtained by 24-hour ambulatory blood pressure monitoring (ABPM). ABPM allows the analysis of indices of BP variability like day and night SD, BP dipping, weighted 24-h SD (wSD), average real variability (ARV). Aim of the present study was to address the relationship between these indices and other markers of vascular subclinical damage in children.

Design and Method: 45 obese children were included. Children underwent vascular measurements, including: (i) office and 24-hour ambulatory BP; (ii) brachial flow-mediated dilatation (FMD), carotid intima media thickness (cIMT), and distensibility (cDC); (iii) systemic arterial stiffness (SIDVP). From ABPM we calculate AASI, sAASI, ARV, SD, SD, systolic and diastolic dipping and wSD.

Results: ARV showed a significant correlation with SIDVP (r = 0.379; p = 0.023). AASI but not sAASI correlated with FMD (r = 0.361; p = 0.031). In the population divided in hypertensive (n = 11)/normotensive (n = 34), ARV was associated with SIDVP only in normotensive (r = 0.446; p = 0.015). In normotensive, z score-BMI was correlated with both sAASI and wSD (respectively 0.340; p = 0.049 and 0.423; p = 0.014), wSD correlated with FMD (r = 0.384; p = 0.048); in hypertensive children, ARV correlated with FMD (r = 0.828; p = 0.011; rspearman = 0.738; p = 0.037). No indices of BP variability correlated with cIMT or cDC.

Conclusions: BP variability, in particular ARV, shows a correlation with systemic but not local vascular stiffness in a sample of obese children, suggesting a relation between daily BP variability and arterial elastic properties. Further studies, especially perspective ones, are needed to clarify the pathophysiological significance of these relations.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Angela Tagetti
AU  - Sara Bonafini
AU  - Cristiano Fava
PY  - 2017
DA  - 2017/12/06
TI  - P158 ASSOCIATION BETWEEN AMBULATORY ARTERIAL STIFFNESS INDEX, MARKERS OF BLOOD PRESSURE VARIABILITY AND INDICES OF SUBCLINICAL VASCULAR DAMAGE IN OBESE CHILDREN
JO  - Artery Research
SP  - 104
EP  - 105
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.179
DO  - 10.1016/j.artres.2017.10.179
ID  - Tagetti2017
ER  -