P23 PREDICTION OF TOTAL AND CAUSE-SPECIFIC MORTALITY INCIDENCE AS WELL AS CARDIOVASCULAR MORBIDITY BY USE OF NON-INVASIVE MEASUREMENT OF CAROTID- FEMORAL PULSE WAVE VELOCITY AS A MEASURE OF ARTERIAL STIFFNESS

DOI

10.1016/j.artres.2017.10.164How to use a DOI?

Abstract

Objective: Arterial stiffness (AS) increases with age and predicts total mortality and total cardiovascular (CV) events. It has also been shown that positive family history (FH+) of cardiometabolic disease influences AS. We aimed to: 1) examine if AS predicts total mortality among elderly subjects, as well as total, fatal, and non-fatal CV events; and 2) to assess if FH+ influences the prediction of AS.

Methods: Participants from the Malmö Diet Cancer CV cohort (MDC-CV; n = 3,056, mean age 71 years, 40% men) in Sweden were examined during 2007–2012. AS was measured with carotid-femoral pulse wave velocity (c-f PWV; Sphygmocor®). Follow-up started from date of measurement and ended at death, emigration or on 31^st December 2014. Hazard ratios (HRs) with 95% confidence intervals were computed using multivariable Cox and competing risks regression (sub-hazard ratio, SHR) adjusting for age, sex, cardiovascular risk factors, prevalent cardiometabolic diseases and FH+.

Results: c-f PWV (per log-unit) significantly predicted total mortality, HR 2.57 (95%CI: 1.28–5.16, p = 0.008), after full adjustment for risk factors, and HR 3.01 (95%CI: 1.41–6.42) after adding FH. The prediction of CV events was of borderline significance, HR 1.85 (95%CI: 0.91–3.78, p = 0.09). FH+ contribution to c-f PWV prediction of non-CV mortality was of borderline significance SHR 2.30 (95%CI: 0.89–5.95, p = 0.085).

Conclusion: Arterial stiffness (c-f PWV) predicts total mortality, even adjusted for family history. Thus c-f PWV is a promising risk marker for total mortality, beyond the prediction offered by conventional risk factors.

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TY  - JOUR
AU  - Peter Nilsson
AU  - Mikael Gottsäter
AU  - Abd al-Hakim Fatehali
PY  - 2017
DA  - 2017/12/06
TI  - P23 PREDICTION OF TOTAL AND CAUSE-SPECIFIC MORTALITY INCIDENCE AS WELL AS CARDIOVASCULAR MORBIDITY BY USE OF NON-INVASIVE MEASUREMENT OF CAROTID- FEMORAL PULSE WAVE VELOCITY AS A MEASURE OF ARTERIAL STIFFNESS
JO  - Artery Research
SP  - 100
EP  - 100
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.164
DO  - 10.1016/j.artres.2017.10.164
ID  - Nilsson2017
ER  -