Artery Research

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Volume 20, Issue C, December 2017, Pages 99 - 99

P22 CIRCADIAN VARIATIONS IN THE CARDIOVASCULAR SYSTEM

Authors
Thomas Weber1, Siegfried Wasserheurer2, Arno Schmidt-Trucksäss3, Enrique Rodilla Sala4, Piotr Jankowski5, Maria Lorenza Muisan6, Cristina Giannatasio7, Ian Wilkinson8, Joerg Kellermair9, Bernhard Hametner2, Jose Maria Pascual4, Robert Zweiker10, Danuta Czarnecka5, Anna Paini6, Massimo Salvetti6, Allessandro Maloberti7, Peter Fitscha11, Kai Mortensen12, Elisabeth Wagner1, Carmel McEniery8, Cornelia Ablasser10
1Cardiology Department, Klinikum Wels-Grieskirchen, Austria
2Center for Health & Bioresources, Department of Health and Environment, Austrian Institute of Technology, Vienna, Austria
3Department of Sport, Exercise and Health, Division Sport and Exercise Medicine, University of Basel, Switzerland
4Department of Medicina Interna, Hospital de Sagunto, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain
51st Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University, Medical College, Krakow, Poland
6Department of Clinical and Experimental Sciences, University of Brescia, Italy
7Cardiology IV, ‘A. De Gasperis’ Department, ASTT Ospedale Niguarda Ca’ Granda, School of Medicine and Surgery Department, Milano-Bicocca University, Milan, Italy
8Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, UK
9Cardiology Department, Kepler University Clinic, Linz, Austria
10Cardiology Department, Medical University Graz, Austria
11Cardiologist, Vienna, Austria
12Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Germany
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.163How to use a DOI?
Abstract

Background: Comprehensive information on 24-hour profiles of pulsatile as well as steady-state hemodynamics in humans is not available yet.

Methods: In 693 healthy individuals (352 men) free from antihypertensive drugs, we performed 24-hour blood pressure (BP) monitoring with a validated oscillometric brachial cuff (mobilograph, i.e.m., Stolberg, Germany). Brachial waveforms were acquired and processed with ARCSolver algorithms to derive information on central pressures, wave reflections, stroke volume and systemic vascular resistance. Nighttime/daytime difference (N/D) was defined as nighttime (01.00–06.00) minus daytime (09.00–21.00) values / daytime values. Patients were categorized as young (Y: 15–40 years; n = 187), middle-aged (M: 41–70 years; n = 446), and old (O: 71–94 years; n = 60).

Results: Averaged 24-hour brachial BP was 123/78 (Y), 127/82 (M), and 126/74 (O) mm Hg. N/D for brachial SBP was −13% (Y), −12% (M), and −5% (O). N/D for heart rate was – 20% (Y), −17% (M), and −15% (O). N/D for central SBP was less pronounced: −4% (Y), −6% (M), and −0% (O).

Brachial pulse pressure (PP) displayed small circadian variations, whereas central PP was higher at nighttime: N/D was 25% (Y), 14% (M), and 17% (O). Consequently, PP amplification was higher at daytime (N/D was −21% (Y), −16% (M), and −12% (O)), and was related to heart rate, age, and gender.

Measures of wave reflections were higher at nighttime, with N/D related to age, heart rate, mean pressure, systemic vascular resistance and stroke volume.

Conclusion: The circadian profiles we provide may serve as reference for cardiovascular diseases and drug studies.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
99 - 99
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.163How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Thomas Weber
AU  - Siegfried Wasserheurer
AU  - Arno Schmidt-Trucksäss
AU  - Enrique Rodilla Sala
AU  - Piotr Jankowski
AU  - Maria Lorenza Muisan
AU  - Cristina Giannatasio
AU  - Ian Wilkinson
AU  - Joerg Kellermair
AU  - Bernhard Hametner
AU  - Jose Maria Pascual
AU  - Robert Zweiker
AU  - Danuta Czarnecka
AU  - Anna Paini
AU  - Massimo Salvetti
AU  - Allessandro Maloberti
AU  - Peter Fitscha
AU  - Kai Mortensen
AU  - Elisabeth Wagner
AU  - Carmel McEniery
AU  - Cornelia Ablasser
PY  - 2017
DA  - 2017/12/06
TI  - P22 CIRCADIAN VARIATIONS IN THE CARDIOVASCULAR SYSTEM
JO  - Artery Research
SP  - 99
EP  - 99
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.163
DO  - 10.1016/j.artres.2017.10.163
ID  - Weber2017
ER  -