P91 GREEN TEA EXTRACT REDUCES LIPID PROFILE, PERCENTAGE OF AORTIC AUGMENTATION INDEX AND INCREASES SOLUBLE RAGE CONCENTRATIONS IN NORMOTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED, DOUBLE-BLINDED, AND PLACEBO- CONTROLLED TRIAL
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Background: Type 2 diabetes mellitus is associated with premature atherosclerosis and arterial stiffening by an accumulation of advanced glycation end-products in vessel wall (1). Green tea polyphenols are considered a cardioprotective substance and may be used as an adjuvant for diabetes treatment, because its ability to stimulates the soluble RAGE secretion (2). There is no clinical evidence of the effect of green tea extract administration on metabolic parameters, arterial stiffness and the soluble RAGE expression.
Material and Methods: A double-blind, placebo-controlled, randomized clinical trial in normotensive patients with type 2 diabetes mellitus was conducted to identify the effect of green tea extract on arterial stiffness, metabolic and anthropometric parameters and on soluble RAGE (sRAGE) with the S100A1 ligand.
Results: We included 20 subjects, there was no difference between groups at baseline. There was a decrease in the green tea extract group on aortic augmentation index (21.12±8.9 to 18.07±9.7, p = 0.045), total cholesterol (203.9±37.6 to 176.9±25.9 mg/dl, p = 0.019) triglycerides (202.6±146.9 to 123.2±64.8 mg/dl, p = 0.023) and an increase in sRAGE (1358.5±390.0 to 1281.1±369.7 p = 0.052).
GTE PLACEBO P Basal n = 10 Final n = 10 Basal n = 10 Final n = 10 Fasting Glucose, mg/dl 169.9±92.3 123.9±69.8 168.1±49.7 171.3±39.8 0.089 Creatinin mg/dl 0.75±0.2 0.81±0.14 0.7±0.2 0.78±0.14 0.853 Total Cholesterol mg/dl 203.9±37.6 176.9±25.9 187.9±44.6 216.1±48.2 0.019* Triglycerids, mg/dl 202.6±146.3 123.9±64.8 159.9±57.0 184.3±93.9 0.023* HDLc, mg/dl 47.9±7.8 44.9±5.2 48±8.9 46.9±10.2 0.529 LDLC. mg/dl 123±32.8 109.4±25.1 92.3±30.2 111.2±53.3 0.436 TGO, U/ml 25.6±10.1 25.3±7.08 40.7±13.8 44.4±26.8 0.971 TGP, U/ml 23.8±13.6 28.9±11.9 35.4±14.5 44.7±25.4 0.912 TFG, naL/min 119.9±56.3 101.8±23.9 120.6±50.2 102.3±22.7 0.739 Values are arithmetic means±SE except for mean differences between groups, which have been adjusted for baseline values. Between-group P values reflect the between-group comparison change-scores from Man Whitney U statistic methodology.
*Significant (p < 0.05) within-group change.
Table 1.Effect of 12 weeks of Green tea extract intervention or placebo on circulating parameters.
Conclusions: Green tea extract reduces lipid levels, percentage of aortic augmentation index and increases soluble RAGE concentrations in normotensive patients with Type 2 Diabetes.
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TY - JOUR AU - Fernando Grover Páez AU - Patricia Quezada Fernandez AU - Mariana Rodriguez de la Cerda AU - David Cardona Müller AU - Jhonatan Trujillo Quiroz AU - Walter Trujillo Rangel AU - Marycruz Barocio Pantoja PY - 2017 DA - 2017/12/06 TI - P91 GREEN TEA EXTRACT REDUCES LIPID PROFILE, PERCENTAGE OF AORTIC AUGMENTATION INDEX AND INCREASES SOLUBLE RAGE CONCENTRATIONS IN NORMOTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED, DOUBLE-BLINDED, AND PLACEBO- CONTROLLED TRIAL JO - Artery Research SP - 87 EP - 88 VL - 20 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2017.10.128 DO - 10.1016/j.artres.2017.10.128 ID - GroverPáez2017 ER -