P91 GREEN TEA EXTRACT REDUCES LIPID PROFILE, PERCENTAGE OF AORTIC AUGMENTATION INDEX AND INCREASES SOLUBLE RAGE CONCENTRATIONS IN NORMOTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED, DOUBLE-BLINDED, AND PLACEBO- CONTROLLED TRIAL

Fernando Grover Páez; Patricia Quezada Fernandez; Mariana Rodriguez de la Cerda; David Cardona Müller; Jhonatan Trujillo Quiroz; Walter Trujillo Rangel; Marycruz Barocio Pantoja

doi:10.1016/j.artres.2017.10.128

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Volume 20, Issue C, December 2017, Pages 87 - 88

P91 GREEN TEA EXTRACT REDUCES LIPID PROFILE, PERCENTAGE OF AORTIC AUGMENTATION INDEX AND INCREASES SOLUBLE RAGE CONCENTRATIONS IN NORMOTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED, DOUBLE-BLINDED, AND PLACEBO- CONTROLLED TRIAL

Authors

Fernando Grover Páez¹^{, 2}^{, 3}, Patricia Quezada Fernandez⁴^{, 5}, Mariana Rodriguez de la Cerda⁴, David Cardona Müller²^{, 6}^{, 7}, Jhonatan Trujillo Quiroz⁴^{, 5}, Walter Trujillo Rangel⁵^{, 4}, Marycruz Barocio Pantoja⁴^{, 5}

¹University of Guadalajara, Physiology Department of the University of Guadalajara, Mexico

²Experimental Therapeutic and Clinic Institute, University of Guadalajara, Mexico

³National System of Researchers Grade 1, National Council of Science and Technology (CONACYT), Mexico

⁴Experimental Therapeutic and Clinic Institute, Physiology Department of the University of Guadalajara, Mexico

⁵PNPC, National Council of Science and Technology (CONACYT), Mexico

⁶National System of Researchers, National Council of science and technology (CONACYT), Mexico

⁷National Council of Cardiology, Mexico

Available Online 6 December 2017.

DOI

10.1016/j.artres.2017.10.128 How to use a DOI?

Abstract

Background: Type 2 diabetes mellitus is associated with premature atherosclerosis and arterial stiffening by an accumulation of advanced glycation end-products in vessel wall (1). Green tea polyphenols are considered a cardioprotective substance and may be used as an adjuvant for diabetes treatment, because its ability to stimulates the soluble RAGE secretion (2). There is no clinical evidence of the effect of green tea extract administration on metabolic parameters, arterial stiffness and the soluble RAGE expression.

Material and Methods: A double-blind, placebo-controlled, randomized clinical trial in normotensive patients with type 2 diabetes mellitus was conducted to identify the effect of green tea extract on arterial stiffness, metabolic and anthropometric parameters and on soluble RAGE (sRAGE) with the S100A1 ligand.

Results: We included 20 subjects, there was no difference between groups at baseline. There was a decrease in the green tea extract group on aortic augmentation index (21.12±8.9 to 18.07±9.7, p = 0.045), total cholesterol (203.9±37.6 to 176.9±25.9 mg/dl, p = 0.019) triglycerides (202.6±146.9 to 123.2±64.8 mg/dl, p = 0.023) and an increase in sRAGE (1358.5±390.0 to 1281.1±369.7 p = 0.052).

	GTE		PLACEBO		P

	Basal n = 10	Final n = 10	Basal n = 10	Final n = 10
Fasting Glucose, mg/dl	169.9±92.3	123.9±69.8	168.1±49.7	171.3±39.8	0.089
Creatinin mg/dl	0.75±0.2	0.81±0.14	0.7±0.2	0.78±0.14	0.853
Total Cholesterol mg/dl	203.9±37.6	176.9±25.9	187.9±44.6	216.1±48.2	0.019^*
Triglycerids, mg/dl	202.6±146.3	123.9±64.8	159.9±57.0	184.3±93.9	0.023^*
HDLc, mg/dl	47.9±7.8	44.9±5.2	48±8.9	46.9±10.2	0.529
LDLC. mg/dl	123±32.8	109.4±25.1	92.3±30.2	111.2±53.3	0.436
TGO, U/ml	25.6±10.1	25.3±7.08	40.7±13.8	44.4±26.8	0.971
TGP, U/ml	23.8±13.6	28.9±11.9	35.4±14.5	44.7±25.4	0.912
TFG, naL/min	119.9±56.3	101.8±23.9	120.6±50.2	102.3±22.7	0.739

Values are arithmetic means±SE except for mean differences between groups, which have been adjusted for baseline values. Between-group P values reflect the between-group comparison change-scores from Man Whitney U statistic methodology.

*

Significant (p < 0.05) within-group change.

Table 1.

Effect of 12 weeks of Green tea extract intervention or placebo on circulating parameters.

Conclusions: Green tea extract reduces lipid levels, percentage of aortic augmentation index and increases soluble RAGE concentrations in normotensive patients with Type 2 Diabetes.

Open Access

This is an open access article distributed under the CC BY-NC license.

References

1.MT Schram, RM Henry, RA van Dijk, PJ Kostense, JM Dekker, G Nijpels, et al., Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes, Hypertension, Vol. 43, No. 2, 2004, pp. 176-81.

2.CM Borges, A Papadimitriou, DA Duarte, JML De Faria, and JBL De Faria, The use of green tea polyphenols for treating residual albuminuria in diabetic nephropathy: A double-blind randomised clinical trial, Scientific Reports, 2016, pp. 6.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 87 - 88
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.128 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Fernando Grover Páez
AU  - Patricia Quezada Fernandez
AU  - Mariana Rodriguez de la Cerda
AU  - David Cardona Müller
AU  - Jhonatan Trujillo Quiroz
AU  - Walter Trujillo Rangel
AU  - Marycruz Barocio Pantoja
PY  - 2017
DA  - 2017/12/06
TI  - P91 GREEN TEA EXTRACT REDUCES LIPID PROFILE, PERCENTAGE OF AORTIC AUGMENTATION INDEX AND INCREASES SOLUBLE RAGE CONCENTRATIONS IN NORMOTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED, DOUBLE-BLINDED, AND PLACEBO- CONTROLLED TRIAL
JO  - Artery Research
SP  - 87
EP  - 88
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.128
DO  - 10.1016/j.artres.2017.10.128
ID  - GroverPáez2017
ER  -

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