P83 A PILOT STUDY TO ASSESS PEAK SYSTOLIC VELOCITY AS A POSSIBLE MARKER OF ATHEROSCLEROTIC BURDEN USING ULTRASOUND

DOI

10.1016/j.artres.2017.10.099How to use a DOI?

Abstract

Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CFD) outputs, which in turn may contribute to IHD pathogenesis.

Methods: A sample of 57 subjects (with IHD: 27, without IHD: 30) had US velocity profiles (left- common carotid artery) determined between 10–12 equi-spaced points. Bezier curve fitting was used to fit the profile through the measured velocity points for a normalised diameter. PSV was correlated against CFD results such as wall shear stress (WSS) [2]. Difference in PSV between individuals with/without IHD was studied via t-test. Linear regression was carried out to see if peak systolic velocity was associated with CFD outputs. Any significant associations were analysed within stratified groups (with/without IHD).

Results: PSV was significantly lower (p = 0.042) in subjects with IHD (with IHD: 53.6±17.3 cm/s, without IHD: 62.8±16.1 cm/s). PSV was associated with carotid bulb average pressure drop (p < 0.001), area of average bulb WSS (<1 Pa: p = 0.016, <2 Pa: p = 0.006, <3 Pa: p = 0.001). All the above associations remained significant in individuals with IHD (average bulb pressure drop: p = 0.001, average bulb WSS (<1 Pa: p = 0.013, <2 Pa: p = 0.008, <3 Pa: p = 0.003). In subjects without IHD, PSV was associated with only average bulb pressure drop (p = 0.016).

Conclusions: This study suggests that further work on PSV and its associations with CFD outputs is required in individuals with and without IHD in various vascular beds.

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TY  - JOUR
AU  - Carola Koenig
AU  - Mark Atherton
AU  - Marco Cavazzuti
AU  - Sudarshan Ramachandran
AU  - Corinna Gomm
AU  - Richard Strange
AU  - Ian Halliday
AU  - Torsten Schenkel
PY  - 2017
DA  - 2017/12/06
TI  - P83 A PILOT STUDY TO ASSESS PEAK SYSTOLIC VELOCITY AS A POSSIBLE MARKER OF ATHEROSCLEROTIC BURDEN USING ULTRASOUND
JO  - Artery Research
SP  - 76
EP  - 76
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.099
DO  - 10.1016/j.artres.2017.10.099
ID  - Koenig2017
ER  -