P83 A PILOT STUDY TO ASSESS PEAK SYSTOLIC VELOCITY AS A POSSIBLE MARKER OF ATHEROSCLEROTIC BURDEN USING ULTRASOUND

Carola Koenig; Mark Atherton; Marco Cavazzuti; Sudarshan Ramachandran; Corinna Gomm; Richard Strange; Ian Halliday; Torsten Schenkel

doi:10.1016/j.artres.2017.10.099

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Volume 20, Issue C, December 2017, Pages 76 - 76

P83 A PILOT STUDY TO ASSESS PEAK SYSTOLIC VELOCITY AS A POSSIBLE MARKER OF ATHEROSCLEROTIC BURDEN USING ULTRASOUND

Authors

Carola Koenig¹, Mark Atherton¹, Marco Cavazzuti¹, Sudarshan Ramachandran², Corinna Gomm², Richard Strange³, Ian Halliday⁴, Torsten Schenkel⁴

¹Brunel University London, UK

²Heart of England Foundation NHS Trust, UK

³Keele University, UK

⁴Sheffield Hallam University, UK

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.099 How to use a DOI?
Abstract: Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CFD) outputs, which in turn may contribute to IHD pathogenesis.

Methods: A sample of 57 subjects (with IHD: 27, without IHD: 30) had US velocity profiles (left- common carotid artery) determined between 10–12 equi-spaced points. Bezier curve fitting was used to fit the profile through the measured velocity points for a normalised diameter. PSV was correlated against CFD results such as wall shear stress (WSS) [2]. Difference in PSV between individuals with/without IHD was studied via t-test. Linear regression was carried out to see if peak systolic velocity was associated with CFD outputs. Any significant associations were analysed within stratified groups (with/without IHD).

Results: PSV was significantly lower (p = 0.042) in subjects with IHD (with IHD: 53.6±17.3 cm/s, without IHD: 62.8±16.1 cm/s). PSV was associated with carotid bulb average pressure drop (p < 0.001), area of average bulb WSS (<1 Pa: p = 0.016, <2 Pa: p = 0.006, <3 Pa: p = 0.001). All the above associations remained significant in individuals with IHD (average bulb pressure drop: p = 0.001, average bulb WSS (<1 Pa: p = 0.013, <2 Pa: p = 0.008, <3 Pa: p = 0.003). In subjects without IHD, PSV was associated with only average bulb pressure drop (p = 0.016).

Conclusions: This study suggests that further work on PSV and its associations with CFD outputs is required in individuals with and without IHD in various vascular beds.
Open Access: This is an open access article distributed under the CC BY-NC license.

Reference

[1]A Ei-Sakka and AM Morsy, Urology, Vol. 64, 2004, pp. 346-50.

[2]E Cecchi et al., 1, Atherosclerosis, Vol. 214, No. 2, Feb 2011, pp. 249-56.

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 20 - C
Pages: 76 - 76
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.099 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Carola Koenig
AU  - Mark Atherton
AU  - Marco Cavazzuti
AU  - Sudarshan Ramachandran
AU  - Corinna Gomm
AU  - Richard Strange
AU  - Ian Halliday
AU  - Torsten Schenkel
PY  - 2017
DA  - 2017/12/06
TI  - P83 A PILOT STUDY TO ASSESS PEAK SYSTOLIC VELOCITY AS A POSSIBLE MARKER OF ATHEROSCLEROTIC BURDEN USING ULTRASOUND
JO  - Artery Research
SP  - 76
EP  - 76
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.099
DO  - 10.1016/j.artres.2017.10.099
ID  - Koenig2017
ER  -

download .riscopy to clipboard