Artery Research

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Volume 20, Issue C, December 2017, Pages 74 - 74

P75 SIGNS OF ACCELERATED CAROTID ATHEROSCLEROSIS IN EARLY TYPE 2 DIABETES ASSESSED BY MAGNETIC RESONANCE IMAGING

Authors
Esben Laugesen1, Pernille Høyem1, Samuel Thrysøe2, Esben Hansen2, Anders Mikkelsen2, 3, Bill Kerwin4, L. Poulsen Per1, K. Hansen Troels1, Y. Kim Won2, 5
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
2The MR Research Centre and Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
3Department of Procurement and Clinical Engineering, Central Denmark Region, Denmark
4University of Washington, Seattle, WA, USA
5Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.091How to use a DOI?
Abstract

Background: Ischemic stroke from carotid plaque embolism remains a major cause of morbidity and mortality in patients with type 2 diabetes (T2DM). However, the effect of T2DM on early carotid plaque burden and composition is sparsely elucidated. We assessed carotid plaque composition by carotid magnetic resonance imaging (MRI) in short duration T2DM patients compared to a sex- and age-matched control group.

Methods: 100 patients with T2DM (duration <5 years) and 100 sex- and age- matched control subjects underwent MRI of the carotid arteries bilaterally in a 1.5 T MRI scanner. Plaque burden was measured as normalized wall index, maximum wall thickness, maximum wall area, and minimum lumen size. Plaque characteristics were quantified by calcified plaque volume, necrotic core volume, and loose matrix volume.

Results: MRI data were available for 149 and 177 carotid arteries from T2DM patients and control subjects, respectively. T2DM was associated with a higher normalized wall index (ratio 1.03 (1.002; 1.06), p = 0.03), a lower minimum lumen area (ratio 0.81(0.74; 0.89), p < 0.001), and lower maximum wall area (ratio 0.94 (0.88; 1.00), p = 0.048) compared to controls. Body mass index (BMI) was associated with maximum wall area and all plaque characteristics independently of diabetes status. BMI≥30 kg/m2 was associated with an 80% increase in total volume of calcified plaque, and a 44% increase in necrotic core volume compared to BMI < 25 kg/m2.

Conclusions: T2DM patients had increased carotid plaque burden and negative remodeling. Obesity was associated with increased carotid artery necrotic core volume and calcification independently of diabetes status.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
74 - 74
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.091How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Esben Laugesen
AU  - Pernille Høyem
AU  - Samuel Thrysøe
AU  - Esben Hansen
AU  - Anders Mikkelsen
AU  - Bill Kerwin
AU  - L. Poulsen Per
AU  - K. Hansen Troels
AU  - Y. Kim Won
PY  - 2017
DA  - 2017/12/06
TI  - P75 SIGNS OF ACCELERATED CAROTID ATHEROSCLEROSIS IN EARLY TYPE 2 DIABETES ASSESSED BY MAGNETIC RESONANCE IMAGING
JO  - Artery Research
SP  - 74
EP  - 74
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.091
DO  - 10.1016/j.artres.2017.10.091
ID  - Laugesen2017
ER  -