P42 24-HOUR CENTRAL BLOOD PRESSURE IS MORE STRONGLY ASSOCIATED TO TARGET ORGAN DAMAGE THAN BRACHIAL BLOOD PRESSURE: FIRST RESULTS OF THE VASOTENS REGISTRY

Stefano Omboni; Igor N. Posokhov; Gianfranco Parati; Vitaliy S. Barkan; Ernesto Cardona Muñoz; Elena A. Grigoricheva; Irina E. Minyukhina; Maria Lorenza Muiesan; Giuseppe Mulè; Iana A. Orlova; Telmo Pereira

doi:10.1016/j.artres.2017.10.072

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Volume 20, Issue C, December 2017, Pages 67 - 68

P42 24-HOUR CENTRAL BLOOD PRESSURE IS MORE STRONGLY ASSOCIATED TO TARGET ORGAN DAMAGE THAN BRACHIAL BLOOD PRESSURE: FIRST RESULTS OF THE VASOTENS REGISTRY

Authors

Stefano Omboni¹, Igor N. Posokhov², Gianfranco Parati³^{, 4}, Vitaliy S. Barkan⁵, Ernesto Cardona Muñoz⁶, Elena A. Grigoricheva⁷, Irina E. Minyukhina⁸, Maria Lorenza Muiesan⁹, Giuseppe Mulè¹⁰, Iana A. Orlova¹¹, Telmo Pereira¹²

¹Clinical Research Unit, Italian Institute of Telemedicine, Varese, Italy

²Hemodynamic Laboratory Ltd, Nizhniy Novgorod, Russian Federation

³Department of Cardiology, Istituto Auxologico Italiano, Milan, Italy

⁴Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

⁵Diagnostics Department, The Hospital within the Russian Railroad Network, Chita, Russian Federation

⁶University of Guadalajara, Dept. of Physiology, Guadalajara, Mexico

⁷South Ural State Medical University, Chelyabinsk, Russian Federation

⁸Volga District Medical Center, Nizhniy Novgorod, Russian Federation

⁹Dipartimento di Scienze Mediche e Chirurgiche, Università di Brescia, Medicina 2, Spedali Civili, Brescia, Italy

¹⁰Unità Operativa di Nefrologia ed Ipertensione, Centro di Riferimento Regionale per l’Ipertensione Arteriosa, Policlinico Paolo Giaccone, Palermo, Italy

¹¹Lomonosov Moscow State University Clinic, State University, Moscow, Russian Federation

¹²Escola Superior de Tecnologia da Saúde de Coimbra, Instituto Politécnico de Coimbra, Coimbra, Portugal

Available Online 6 December 2017.

DOI

10.1016/j.artres.2017.10.072 How to use a DOI?

Abstract

Objective: In the present analysis of the VASOTENS study [1] baseline data, we checked whether organ damage of hypertension (TOD) i) is better associated with 24-hour central than peripheral BP and ii) is related to ambulatory arterial stiffness, estimated by pulse wave velocity (PWV) and augmentation index (AIx).

Methods: TOD in 334 hypertensive patients (mean age 53±15, 52% males, 45% treated) was estimated by calculation of left ventricular mass index (LVMI), intima-media thickness (IMT) and creatinine clearance (CC). 24-hour indices were estimated through the Vasotens technology [2]. 24-hour brachial (bSBP) and aortic systolic BP (aSBP), standard deviation of bSBP, PWV and AIx were obtained. Bivariate and multivariate analysis (stepwise linear regression) was used.

Results: A significant relation was found for age, bSBP and aSBP vs. LVMI and IMT (see table). IMT was also significantly related to SBP variability and arterial stiffness, whereas age, SBP variability and AIx were significantly associated with СС. In the multivariate analysis, including all ••••variables entered in the bivariate model, adjusted by sex, statistically significant (p < 0.001) association was observed for aSBP and age with LVMI (standardized regression coefficient 0.25 and 0.18, respectively), and for age with IMT (0.56) and CC (−0.53).

Correlation coefficients	LVMI (g/m²)	IMT (mm)	CC (ml/min)
Age (years)	0.25^***	0.56^**	−0.53^**
bSBP (mmHg)	0.23^***	0.24^**	−0.01
aSBP (mmHg)	0.28^***	0.26^**	−0.05
SD bSBP (mmHg)	0.01	0.24^**	−0.19^*
PWV (m/s)	0.09	0.17^*	−0.14
AI (%)	0.07	0.22^**	−0.18^*

***

p < 0.001 ;

**

p < 0.01;

*

p < 0.05.

Conclusions: In hypertensive patients age appears to be the major determinant of TOD, with central SBP, and marginally peripheral SBP, PWV and AIx, also playing a significant role. Our results suggest that estimation of 24-hour central hemodynamics and arterial stiffness in ambulatory conditions may help improve the individualized assessment of the BP-associated TOD.

Open Access

This is an open access article distributed under the CC BY-NC license.

References

[1]S Omboni, IN Posokhov, G Parati, A Avolio, AN Rogoza, YV Kotovskaya, G Mulè, ML Muiesan, IA Orlova, EA Grigoricheva, E Cardona Muñoz, PH Zelveian, T Pereira, and JM Peixoto Maldonado, Vascular Health Assessment of The Hypertensive Patients (VASOTENS) Registry: Study Protocol of an International, Web-Based Telemonitoring Registry for Ambulatory Blood Pressure and Arterial Stiffness, JMIR Res Protoc, Vol. 5, 2016, pp. e137.

[2]S Omboni, IN Posokhov, YV Kotovskaya, AD Protogerou, and J Blacher, Twenty-Four-Hour Ambulatory Pulse Wave Analysis in Hypertension Management: Current Evidence and Perspectives, Curr Hypertens Rep, Vol. 18, 2016, pp. 72.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 67 - 68
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.072 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Stefano Omboni
AU  - Igor N. Posokhov
AU  - Gianfranco Parati
AU  - Vitaliy S. Barkan
AU  - Ernesto Cardona Muñoz
AU  - Elena A. Grigoricheva
AU  - Irina E. Minyukhina
AU  - Maria Lorenza Muiesan
AU  - Giuseppe Mulè
AU  - Iana A. Orlova
AU  - Telmo Pereira
PY  - 2017
DA  - 2017/12/06
TI  - P42 24-HOUR CENTRAL BLOOD PRESSURE IS MORE STRONGLY ASSOCIATED TO TARGET ORGAN DAMAGE THAN BRACHIAL BLOOD PRESSURE: FIRST RESULTS OF THE VASOTENS REGISTRY
JO  - Artery Research
SP  - 67
EP  - 68
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.072
DO  - 10.1016/j.artres.2017.10.072
ID  - Omboni2017
ER  -

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