P45 RENIN AT DIFFERENT PHYSICAL ACTIVITY LEVELS IN A BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY

Johannes van Rooyen; Hugo Huisman; Leonè Malan; Catharina Mels; Ruan Kruger; Lebo Gafane-Matemane; Shani Botha; Alta Schutte

doi:10.1016/j.artres.2017.10.073

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Volume 20, Issue C, December 2017, Pages 68 - 68

P45 RENIN AT DIFFERENT PHYSICAL ACTIVITY LEVELS IN A BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY

Authors

Johannes van Rooyen¹, Hugo Huisman², Leonè Malan², Catharina Mels², Ruan Kruger², Lebo Gafane-Matemane², Shani Botha², Alta Schutte²

¹Hypertension in Africa Research Team (HART) and South African Medical Research Council (SaMRC) Unit for Hypertension and Cardiovascular Disease, South Africa

²Hypertension in Africa Research Team (HART) and South African Medical Research Council (SaMRC), South Africa

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.073 How to use a DOI?
Abstract: Background and objectives: It is widely accepted that regular physical exercise reduces the BP, particularly in hypertensive individuals. It is recommended in the prevention of hypertension to assist in BP control. The BP lowering mechanisms of exercise remain largely elusive, we therefore evaluated the RAAS as a regulator of arterial BP.

Methods: The sub-study was embedded in the African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African- PREDICT) and included 111 white and 99 black participants aged 20–30 years.

Office- and central blood pressure as well as other cardiovascular variables were measured. Renin was analysed with an ELISA- and aldosterone with a RIA kit.

Results: The BP decreased significantly in the white but not in the black participants when tertiles for physical activity levels were compared. The total renin (renin + prorenin) level decreased significantly from 789.2 to 700.0 pg/ml (p = 0.04) in the white but not in the black participants (821.6 to 806.6 pg/ml; p = 0.84) with high physical activity level. In multiple regression analysis, in the white participants, MAP and aldosterone contributed significantly and independently to the low renin in the third percentile for physical activity level. This was not evident in the black participants.

Conclusion: Only in white participants high physical activity levels were associated with decreased blood pressure and the RAAS may be an important mechanism in this regard.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 68 - 68
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.073 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Johannes van Rooyen
AU  - Hugo Huisman
AU  - Leonè Malan
AU  - Catharina Mels
AU  - Ruan Kruger
AU  - Lebo Gafane-Matemane
AU  - Shani Botha
AU  - Alta Schutte
PY  - 2017
DA  - 2017/12/06
TI  - P45 RENIN AT DIFFERENT PHYSICAL ACTIVITY LEVELS IN A BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY
JO  - Artery Research
SP  - 68
EP  - 68
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.073
DO  - 10.1016/j.artres.2017.10.073
ID  - vanRooyen2017
ER  -

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