P45 RENIN AT DIFFERENT PHYSICAL ACTIVITY LEVELS IN A BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY
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- 10.1016/j.artres.2017.10.073How to use a DOI?
- Abstract
Background and objectives: It is widely accepted that regular physical exercise reduces the BP, particularly in hypertensive individuals. It is recommended in the prevention of hypertension to assist in BP control. The BP lowering mechanisms of exercise remain largely elusive, we therefore evaluated the RAAS as a regulator of arterial BP.
Methods: The sub-study was embedded in the African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African- PREDICT) and included 111 white and 99 black participants aged 20–30 years.
Office- and central blood pressure as well as other cardiovascular variables were measured. Renin was analysed with an ELISA- and aldosterone with a RIA kit.
Results: The BP decreased significantly in the white but not in the black participants when tertiles for physical activity levels were compared. The total renin (renin + prorenin) level decreased significantly from 789.2 to 700.0 pg/ml (p = 0.04) in the white but not in the black participants (821.6 to 806.6 pg/ml; p = 0.84) with high physical activity level. In multiple regression analysis, in the white participants, MAP and aldosterone contributed significantly and independently to the low renin in the third percentile for physical activity level. This was not evident in the black participants.
Conclusion: Only in white participants high physical activity levels were associated with decreased blood pressure and the RAAS may be an important mechanism in this regard.
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TY - JOUR AU - Johannes van Rooyen AU - Hugo Huisman AU - Leonè Malan AU - Catharina Mels AU - Ruan Kruger AU - Lebo Gafane-Matemane AU - Shani Botha AU - Alta Schutte PY - 2017 DA - 2017/12/06 TI - P45 RENIN AT DIFFERENT PHYSICAL ACTIVITY LEVELS IN A BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY JO - Artery Research SP - 68 EP - 68 VL - 20 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2017.10.073 DO - 10.1016/j.artres.2017.10.073 ID - vanRooyen2017 ER -