Artery Research

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Volume 20, Issue C, December 2017, Pages 66 - 66

P39 LEFT VENTRICULAR STRUCTURE AND FUNCTION IN RELATION TO PERIPHERAL AND CENTRAL BLOOD PRESSURE IN A GENERAL POPULATION

Authors
Wenyi Yang1, Ljupcho Efremov1, Zhen-Yu Zhang1, Nicholas Cauwenberghs1, Lutgarde Thijs1, Fang-Fei Wei1, Qi-Fang Huang1, Blerim Mujaj1, Aernout Luttun2, Peter Verhamme2, Tatiana Kuznetsova1, Jan Staessen1
1Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, Faculty of Medicine, University of Leuven, Leuven, Belgium
2Centre for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences, Faculty of Medicine, University of Leuven, Leuven, Belgium
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.069How to use a DOI?
Abstract

Background: Central blood pressure (BP) is a predictor of target organ damage. No previous study addressed the question to what extent central compared with peripheral is related to left ventricular (LV) structure and function in a general population.

Methods: In 577 Flemish recruited from the general population (47.8% women; mean age 50.5 years), we assessed the multivariable-adjusted associations of echocardiographic LV structure and systolic and diastolic LV function (Vivid7 Pro device; EchoPac software, version 4.0.4; GE Vingmed, Horten, Norway) with peripheral and central pressure, as recorded by radial applanation tonometry (SphygmoCor software, version 9.0). Association sizes were expressed per 15/10 mmHg increment in peripheral or central systolic/diastolic BP.

Results: Peripheral compared with central systolic BP was 10.2 mm Hg higher (P < 0.0001), whereas diastolic BP was similar peripherally and centrally (P = 0.50). Associations were closer (P≤0.020) with central than peripheral systolic BP for LV mass (+0.59 g/m2) and left atrial volume (+0.29 ml/m2) indexed to body surface area, peak A transmitral flow (+0.12 cm/s), peak e′ mitral annular movement (−0.18 cm/s) and the E/A ratio (−0.017). Associations were closer (P≤0.038) with central than peripheral diastolic BP for left atrial volume index (+0.289 ml/m2), e′ (−0.123 cm/s) and E/e′ (+0.094). Ejection fraction and global longitudinal strain were similarly associated with central and peripheral systolic (P≥0.62) and diastolic (P≥0.18) BP.

Conclusions: In asymptomatic people recruited from the general population, LV mass and atrial volume indexes and selected haemodynamic measurements reflecting diastolic LV function are slightly but significantly closer associated with central than peripheral BP.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
66 - 66
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.069How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Wenyi Yang
AU  - Ljupcho Efremov
AU  - Zhen-Yu Zhang
AU  - Nicholas Cauwenberghs
AU  - Lutgarde Thijs
AU  - Fang-Fei Wei
AU  - Qi-Fang Huang
AU  - Blerim Mujaj
AU  - Aernout Luttun
AU  - Peter Verhamme
AU  - Tatiana Kuznetsova
AU  - Jan Staessen
PY  - 2017
DA  - 2017/12/06
TI  - P39 LEFT VENTRICULAR STRUCTURE AND FUNCTION IN RELATION TO PERIPHERAL AND CENTRAL BLOOD PRESSURE IN A GENERAL POPULATION
JO  - Artery Research
SP  - 66
EP  - 66
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.069
DO  - 10.1016/j.artres.2017.10.069
ID  - Yang2017
ER  -