Artery Research

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Volume 20, Issue C, December 2017, Pages 66 - 67

P40 DOES ARTERIAL AGEING DIFFER BETWEEN EUROPEANS AND JAPANESE AND KOREAN PATIENT SAMPLES? RESULTS FROM CURRENT UK STUDIES

Authors
F.A. Kirkham1, C. Mills2, K. Nambiar1, 3, J. Timeyin1, K.A. Davies1, 3, F. Kern3, J.K. Cruickshank2, C. Rajkumar1, 3
1Brighton and Sussex University Hospital Trust, East Sussex, UK
2Guys and St Thomas’ Hospital, King’s College and King’s Health Partners, UK
3Brighton and Sussex Medical School, University of Sussex, UK
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.070How to use a DOI?
Abstract

Objective: Vascular stiffness has long been linked with the ageing process. However, it is only since the development of accurate methods for measuring arterial compliance that unravelling this relationship has become possible. Arterial stiffening over time appears to differ between ethnic groups and/or geographic areas. We investigated how the cardio-ankle vascular index (CAVI) varied with chronological age to make initial comparisons of its change with age between this European study and published data from Japanese and Korean patient populations.

Method: 312 participants (180 men, 132 women), age 63.7±12.9 (mean±SD), range 25–92 years. The following were measured: CAVI using VaSera VS-1500N® (Fukuda Denshi, Japan); brachial BP using OMRON705-IT; baseline characteristics and physical examination of cardiovascular health. These data are from current UK studies of healthy volunteers with approximately 20% having two or more cardiovascular risk factors.

Results: CAVI was significantly correlated with age (r = 0.63, p < 0.001), more closely in men (r = 0.71, p < 0.001) than women (r = 0.54, p < 0.001). These data were used to create a preliminary set of ‘usual’ average CAVI values for each age category (Table) and compared against data from Japan [1] and Korea [2] (plot 1 & 2). Korean men had lower CAVI values at each age.

Age category (years) CAVI mean (SD)
<40 6.83 (0.76)
40–49 7.22 (0.86)
50–59 8.20(1.29)
60–69 8.87 (1.24)
70–79 9.60 (1.36)
80–89 11.11 (1.60)

Conclusions: This suggests CAVI is closely related to ageing and may be a useful indicator of vascular age. In initial comparisons, the slope of arterial ‘ageing’ may be steeper for Europeans, especially men over 60 years, than for Japanese and particularly Koreans, but detailed analysis has not yet been done due to lack of raw data.

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This is an open access article distributed under the CC BY-NC license.

References

[1]Namekata et al., Establishing baseline criteria of cardio-ankle vascular index as a new indicator of arteriosclerosis: a cross-sectional study, BMC Cardiovascular Disorders, Vol. 11, 2011, pp. 51.
[2]SY Choi et al., Age associated increase in arterial stiffness measured according to the cardio-ankle vascular index without blood pressure changes in healthy adults, Journal of Atherosclerosis and Thrombosis, Vol. 20, No. 12, 2013, pp. 911-923.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
66 - 67
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.070How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - F.A. Kirkham
AU  - C. Mills
AU  - K. Nambiar
AU  - J. Timeyin
AU  - K.A. Davies
AU  - F. Kern
AU  - J.K. Cruickshank
AU  - C. Rajkumar
PY  - 2017
DA  - 2017/12/06
TI  - P40 DOES ARTERIAL AGEING DIFFER BETWEEN EUROPEANS AND JAPANESE AND KOREAN PATIENT SAMPLES? RESULTS FROM CURRENT UK STUDIES
JO  - Artery Research
SP  - 66
EP  - 67
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.070
DO  - 10.1016/j.artres.2017.10.070
ID  - Kirkham2017
ER  -