4.8 ARTERIAL STIFFNESS AND ITS RELATIONSHIP TO MORTALITY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

DOI

10.1016/j.artres.2017.10.046How to use a DOI?

Abstract

Background and aim: Several studies (1,2) suggest that patients with peripheral artery disease (PAD) show an increase in arterial stiffness, nevertheless the impact on mortality is less documented. (3)

Methods: 228 PAD patients mean age (68 ± 9 years) were followed-up for 4,8 ± 2 years. Anthropometric and clinical measurements were collected, ankle-brachial index (ABI) was estimated with standard protocol and hemodynamic parameters (central blood pressure, aortic pulse wave velocity [aPWV], augmentation index [Aix]) were measured using applanation tonometry. Prognostic factors of mortality were identified by Cox proportional hazards regression model.

Results: During follow-up 26 (11,6%) deaths occurred. Among them, 5 (19%) were of cardiovascular origin. The Cox analysis applied to data relative to the third tertile of aPWV (11.4–21.4, m/s), is significant for age, (p = 0.039), smoking history (p = 0.0003) non use of lipid lowering drugs (p = 0.026) and lower height (p = 0.007) but not for aPWV (p = 0.312), Aix (p = 0.075) and ABI (p = 0.305).

Conclusions: The present study provides further insights into the lack of association between large artery stiffness, pressure wave reflections and mortality in PAD patients.

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TY  - JOUR
AU  - Gabriel Dimitrov
AU  - Giovanni Scandale
AU  - Martino Recchia
AU  - Edoardo Perilli
AU  - Marzio Minola
AU  - Gianni Carzaniga
AU  - Maria Carotta
AU  - Mariella Catalano
PY  - 2017
DA  - 2017/12/06
TI  - 4.8 ARTERIAL STIFFNESS AND ITS RELATIONSHIP TO MORTALITY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE
JO  - Artery Research
SP  - 58
EP  - 58
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.046
DO  - 10.1016/j.artres.2017.10.046
ID  - Dimitrov2017
ER  -