Artery Research

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Volume 20, Issue C, December 2017, Pages 58 - 58

4.8 ARTERIAL STIFFNESS AND ITS RELATIONSHIP TO MORTALITY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

Authors
Gabriel Dimitrov1, Giovanni Scandale1, Martino Recchia2, Edoardo Perilli1, Marzio Minola1, Gianni Carzaniga2, Maria Carotta1, Mariella Catalano2
1Research Center on Vascular Diseases and Angiology Unit, University of Milan, Milan, Italy
2Research Center on vascular Diseases, University of Milan, Milan, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.046How to use a DOI?
Abstract

Background and aim: Several studies (1,2) suggest that patients with peripheral artery disease (PAD) show an increase in arterial stiffness, nevertheless the impact on mortality is less documented. (3)

Methods: 228 PAD patients mean age (68 ± 9 years) were followed-up for 4,8 ± 2 years. Anthropometric and clinical measurements were collected, ankle-brachial index (ABI) was estimated with standard protocol and hemodynamic parameters (central blood pressure, aortic pulse wave velocity [aPWV], augmentation index [Aix]) were measured using applanation tonometry. Prognostic factors of mortality were identified by Cox proportional hazards regression model.

Results: During follow-up 26 (11,6%) deaths occurred. Among them, 5 (19%) were of cardiovascular origin. The Cox analysis applied to data relative to the third tertile of aPWV (11.4–21.4, m/s), is significant for age, (p = 0.039), smoking history (p = 0.0003) non use of lipid lowering drugs (p = 0.026) and lower height (p = 0.007) but not for aPWV (p = 0.312), Aix (p = 0.075) and ABI (p = 0.305).

Conclusions: The present study provides further insights into the lack of association between large artery stiffness, pressure wave reflections and mortality in PAD patients.

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This is an open access article distributed under the CC BY-NC license.

References

1.NM Van Popele, DE Grobbee, ML Bots, R Asmar, J Topouchian, RS Reneman, APG Hoeks, DAM van der Kuip, A Hofman, and JCM Witteman, Association between arterial stiffness and atherosclerosis. The Rotterdam Study, Stroke, Vol. 32, 2001, pp. 454-460.
2.M Catalano, G Scandale, G Carzaniga, M Cinquini, M Minola, G Dimitrov, and M Carotta, Increased aortic stiffness and related factors in patients with peripheral arterial disease, J Clin Hypertens, Vol. 15, 2013, pp. 712-716.
3.J Kals, J Lieberg, P Kampus, M Zagura, J Eha, and M Zilmer, Prognostic impact of arterial stiffness in patients with symptomatic peripheral arterial disease, Eur J Vasc Endovasc Surg, Vol. 48, 2014, pp. 308-315.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
58 - 58
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.046How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Gabriel Dimitrov
AU  - Giovanni Scandale
AU  - Martino Recchia
AU  - Edoardo Perilli
AU  - Marzio Minola
AU  - Gianni Carzaniga
AU  - Maria Carotta
AU  - Mariella Catalano
PY  - 2017
DA  - 2017/12/06
TI  - 4.8 ARTERIAL STIFFNESS AND ITS RELATIONSHIP TO MORTALITY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE
JO  - Artery Research
SP  - 58
EP  - 58
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.046
DO  - 10.1016/j.artres.2017.10.046
ID  - Dimitrov2017
ER  -