Artery Research

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Volume 24, Issue C, December 2018, Pages 127 - 127

P162 ARTERIAL STIFFNESS AND BODY COMPOSITION IN CHILDREN AND ADOLESCENTS

Authors
Tommy Cai1, 2, Alice Meroni1, Hasthi Dissanayake1, Melinda Phang1, Ahmad Qasem3, Julian Ayer1, 4, Mark Butlin3, Alberto Avolio3, David Celermajer1, 5, Michael Skilton1
1School of Medicine, University of Sydney, Sydney, Australia
2Royal Prince Alfred Hospital, Sydney, Australia
3The Australian School of Advanced Medicine, Macquarie University, Sydney, Australia
4Heart Centre for Children, The Children’s Hospital at Westmead, Sydney, Australia
5Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.215How to use a DOI?
Abstract

Objectives: Carotid-femoral pulse wave velocity (cfPWV) is a validated non-invasive measure of aortic stiffness. Risk factors for cfPWV are well described in adulthood, and furthermore cfPWV is associated with incident cardiovascular disease in adults (1). However, risk factors for arterial stiffness in childhood are poorly described (2). Accordingly, we sought to determine the risk factors for cfPWV in childhood and adolescence and hypothesized that cfPWV would be higher amongst those with greater adiposity.

Methods: We prospectively recruited 88 healthy children (mean age = 11.0 ± 5.3 years old). Age, weight, height, and blood pressure were measured. cfPWV was assessed using a semi-automated cuff-based device (Sphygmocor XCEL; AtCor Medical, Australia), and body composition using air displacement plethysmography (BOD POD; Cosmed, Italy) (3). Associations with cfPWV were determined by multivariable linear regression, with subsequent mediation analyses to inform likely causal pathways.

Results: After adjusting for age and sex, cfPWV was significantly associated with weight, body mass index (BMI), systolic blood pressure, mean blood pressure, heart rate, and lean body mass (LBM), while LBM was significantly associated with height, weight, BMI and fat mass (Table 1). After further adjusting for weight, mean blood pressure and heart rate, LBM remained significantly associated with cfPWV (ß = 0.68; p = 0.007). Mediation analyses indicate that weight mediates the association between age and cfPWV (PM = 76%), and that LBM mediates the relationship between weight and cfPWV (Figure 1).

Conclusion: Higher cfPWV in healthy children and adolescents is a function of growth, and this association may be in turn mediated by higher LBM rather than adiposity.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
127 - 127
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.215How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Tommy Cai
AU  - Alice Meroni
AU  - Hasthi Dissanayake
AU  - Melinda Phang
AU  - Ahmad Qasem
AU  - Julian Ayer
AU  - Mark Butlin
AU  - Alberto Avolio
AU  - David Celermajer
AU  - Michael Skilton
PY  - 2018
DA  - 2018/12/04
TI  - P162 ARTERIAL STIFFNESS AND BODY COMPOSITION IN CHILDREN AND ADOLESCENTS
JO  - Artery Research
SP  - 127
EP  - 127
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.215
DO  - 10.1016/j.artres.2018.10.215
ID  - Cai2018
ER  -