Artery Research

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Volume 24, Issue C, December 2018, Pages 127 - 127

P161 RELATIONSHIP OF FIBRINOGEN WITH ARTERIAL STIFFNESS IS DIFFERENT ACCORDING TO GENDER. EVA STUDY

Authors
Leticia Gomez-Sanchez1, Marta Gomez-Sanchez1, Natalia Sanchez-Aguadero2, Cristina Lugones-Sanchez2, Maria C. Patino-Alonso1, Sara Mora-Simon1, Jose A. Maderuelo-Fernandez2, Emiliano Rodriguez-Sanchez2
1Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center, Salamanca, Spain
2Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center, Health Service of Castilla y León (SACyL), Salamanca, Spain
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.214How to use a DOI?
Abstract

Objectives: To analyze the association of arterial stiffness with the fibrinogen in general population without previous cardiovascular diseases. Differences by gender.

Methods: A cross-sectional study. Study population: From the population assigned to the participating healthcare centres, a cluster random sampling stratified by age and gender was performed to obtain 501 participants aged between 35 and 75, 100 per decade, (50% women) without cardio or cerebrovascular disease. Measurements: pulse wave velocity femoral carotid (cfPWV) was determined using the SphygmoCor System and Cardio Anckle Vascular Index (CAVI) using the VaSera. Plasma fibrinogen was measured in blood.

Results: Mean values: age 55.9 ± 14.2 years (Males = 65.9 ± 14.3 years, Females = 55.8 ± 14.2 years, p = 0.935); CAVI:8.0 ± 1.4 (Males = 8.1 ± 1.5, Females = 7.9 ± 1.4, p = 0.043); cfPWV: 6.5 ± 2.0 m/sec (Males=6.8 ± 2.2 m/sec, Females=6.2 ± 1.8m/sec, p < 0.001) and fibrinogen: 314 ± 70 mg/Dl (Males = 198 ± 65 mg/Dl, Females = 330 ± 71 mg/Dl, p < 0.001). CAVI and CfPWV showed positive correlation with fibrinogen (r = 0.248 and r = 0.147 in males p < 005 in both cases), but not in the females (r = 0.126 and r = 0.101 p > 0.05 in both cases). In the multiple regression analysis after adjusting for age, cardiovascular risk factors, drugs and lifestyles, the association of CAVI with fibrinogen was β = 0.249 (95% CI 0.033to0.464) p = 0.024, and of the cfPWV with fibrinogen was β = 0.01 (95% CI -0.031 to 0.042) p = 0.684 in males, without finding association between CAVI, cfPWV with fibrinogen in the case of females (p = 0.144 and p = 0.825 respectively).

Conclusions: CAVI and cfPWV showed a positive correlation to fibrinogen in males in general population without previous cardiovascular diseases, but not in females. However, after adjusting for confounding factors, the association only remains with CAVI in males.

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This is an open access article distributed under the CC BY-NC license.

References

1.J Wykretowicz, P Guzik, T Krauze, R Marciniak, M Komarnicki, J Piskorski, et al., Fibrinogen and d-dimer in contrasting relation with measures of wave reflection and arterial stiffness, Scand J Clin Lab Invest., Vol. 72, No. 8, Dec 2012, pp. 629-34.
2.C Vlachopoulos, P Pietri, K Aznaouridis, G Vyssoulis, C Vasiliadou, A, T Bratsas, et al., Relationship of fibrinogen with arterial stiffness and wave reflections, J Hypertens, Vol. 25, No. 10, Oct 2007, pp. 2110-6.
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Journal
Artery Research
Volume-Issue
24 - C
Pages
127 - 127
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.214How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Leticia Gomez-Sanchez
AU  - Marta Gomez-Sanchez
AU  - Natalia Sanchez-Aguadero
AU  - Cristina Lugones-Sanchez
AU  - Maria C. Patino-Alonso
AU  - Sara Mora-Simon
AU  - Jose A. Maderuelo-Fernandez
AU  - Emiliano Rodriguez-Sanchez
PY  - 2018
DA  - 2018/12/04
TI  - P161 RELATIONSHIP OF FIBRINOGEN WITH ARTERIAL STIFFNESS IS DIFFERENT ACCORDING TO GENDER. EVA STUDY
JO  - Artery Research
SP  - 127
EP  - 127
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.214
DO  - 10.1016/j.artres.2018.10.214
ID  - Gomez-Sanchez2018
ER  -